Chang Yu-Hsuan, Kumar Ramya, Ng Tze Hann, Wang Han-Ching
Department of Biotechnology and Bioindustry Sciences, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, Taiwan, ROC.
Department of Biotechnology and Bioindustry Sciences, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, Taiwan, ROC.
Dev Comp Immunol. 2018 Mar;80:53-66. doi: 10.1016/j.dci.2017.03.003. Epub 2017 Mar 7.
The possibility of immunological memory in invertebrates is a topic that has recently attracted a lot of attention. Today, even vertebrates are known to exhibit innate immune responses that show memory-like properties, and since these responses are triggered by cells that are involved in the innate immune system, it seems that immune specificity and immune memory do not necessarily require the presence of B cells and T cells after all. This kind of immune response has been called "immune priming" or "trained immunity". In this report, we review recent observations and our current understanding of immunological memory within the innate immune system in cultured shrimp and crayfish after vaccination with live vaccine, killed vaccine and subunit vaccines. We also discuss the possible mechanisms involved in this immune response.
无脊椎动物中免疫记忆的可能性是一个最近备受关注的话题。如今，甚至已知脊椎动物会表现出具有记忆样特性的先天免疫反应，并且由于这些反应是由参与先天免疫系统的细胞触发的，所以似乎免疫特异性和免疫记忆终究不一定需要B细胞和T细胞的存在。这种免疫反应被称为“免疫致敏”或“训练免疫”。在本报告中，我们回顾了近期的观察结果以及我们目前对养殖虾和小龙虾在用活疫苗、灭活疫苗和亚单位疫苗接种后先天免疫系统内免疫记忆的理解。我们还讨论了这种免疫反应涉及的可能机制。
