• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

中药水煎剂对大鼠肝硬化的肝保护作用

Hepatoprotective Effects of Chinese Medicine Herbs Decoction on Liver Cirrhosis in Rats.

作者信息

Mat-Rahim Nor Aziyah, Lim Tong-Hye, Nor-Amdan Nur-Asyura, AbuBakar Sazaly

机构信息

Tropical Infectious Diseases Research and Education Center (TIDREC), Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia; Virology Unit, Institute for Medical Research, Jalan Pahang, 50588 Kuala Lumpur, Malaysia.

Herbitec (M) Sdn Bhd, 11-2 Jalan Sri Hartamas 7, Taman Sri Hartamas, 50480 Kuala Lumpur, Malaysia.

出版信息

Evid Based Complement Alternat Med. 2017;2017:6125829. doi: 10.1155/2017/6125829. Epub 2017 Feb 9.

DOI:10.1155/2017/6125829
PMID:28280515
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5322457/
Abstract

Hepatoprotective and curative activities of aqueous extract of decoction containing 10 Chinese medicinal herbs (HPE-XA-08) were evaluated in Sprague-Dawley albino rats with liver damage induced by thioacetamide (TAA). These activities were assessed by investigating the liver enzymes level and also histopathology investigation. Increases in alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT) levels were observed in rats with cirrhotic liver. No significant alterations of the liver enzymes were observed following treatment with HPE-XA-08. Histopathology examination of rats treated with HPE-XA-08 at 250 mg/kg body weight, however, exhibited moderate liver protective effects. Reduced extracellular matrix (ECM) proteins within the hepatocytes were noted in comparison to the cirrhotic liver. The curative effects of HPE-XA-08 were observed with marked decrease in the level of ALP (more than 3x) and level of GGT (more than 2x) in cirrhotic rat treated with 600 mg/kg body weight HPE-XA-08 in comparison to cirrhotic rat treated with just water diluent. Reversion of cirrhotic liver to normal liver condition in rats treated with HPE-XA-08 was observed. Results from the present study suggest that HPE-XA-08 treatment assisted in the protection from liver cirrhosis and improved the recovery of cirrhotic liver.

摘要

在硫代乙酰胺（TAA）诱导肝损伤的Sprague-Dawley白化大鼠中，评估了含10味中药的水煎液提取物（HPE-XA-08）的保肝和治疗活性。通过检测肝酶水平和组织病理学检查来评估这些活性。在肝硬化大鼠中观察到碱性磷酸酶（ALP）和γ-谷氨酰转移酶（GGT）水平升高。用HPE-XA-08治疗后，未观察到肝酶有明显变化。然而，以250mg/kg体重的HPE-XA-08治疗的大鼠的组织病理学检查显示出中度的肝脏保护作用。与肝硬化肝脏相比，肝细胞内的细胞外基质（ECM）蛋白减少。与仅用水稀释剂治疗的肝硬化大鼠相比，在以600mg/kg体重的HPE-XA-08治疗的肝硬化大鼠中观察到HPE-XA-08的治疗效果，ALP水平（超过3倍）和GGT水平（超过2倍）显著降低。在用HPE-XA-08治疗的大鼠中观察到肝硬化肝脏恢复到正常肝脏状态。本研究结果表明，HPE-XA-08治疗有助于预防肝硬化并改善肝硬化肝脏的恢复。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dccf/5322457/fed15e7b4d2e/ECAM2017-6125829.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dccf/5322457/58bb478aa6f8/ECAM2017-6125829.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dccf/5322457/fed15e7b4d2e/ECAM2017-6125829.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dccf/5322457/58bb478aa6f8/ECAM2017-6125829.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dccf/5322457/fed15e7b4d2e/ECAM2017-6125829.002.jpg

相似文献

1
Hepatoprotective Effects of Chinese Medicine Herbs Decoction on Liver Cirrhosis in Rats.中药水煎剂对大鼠肝硬化的肝保护作用
Evid Based Complement Alternat Med. 2017;2017:6125829. doi: 10.1155/2017/6125829. Epub 2017 Feb 9.
2
Estrogen Deficiency Potentiates Thioacetamide-Induced Hepatic Fibrosis in Sprague-Dawley Rats.雌激素缺乏增强硫代乙酰胺诱导的 Sprague-Dawley 大鼠肝纤维化。
Int J Mol Sci. 2019 Jul 29;20(15):3709. doi: 10.3390/ijms20153709.
3
Influence of olive and rosemary leaves extracts on chemically induced liver cirrhosis in male rats.橄榄叶和迷迭香叶提取物对雄性大鼠化学诱导肝硬化的影响。
Saudi J Biol Sci. 2015 Mar;22(2):157-63. doi: 10.1016/j.sjbs.2014.08.005. Epub 2014 Sep 17.
4
Protective effects of Rosmarinus tomentosus ethanol extract on thioacetamide-induced liver cirrhosis in rats.
Phytomedicine. 2006 Jan;13(1-2):101-8. doi: 10.1016/j.phymed.2004.06.024. Epub 2005 Jun 27.
5
Expression patterns of cell cycle-related proteins in a rat cirrhotic model induced by CCl4 or thioacetamide.四氯化碳或硫代乙酰胺诱导的大鼠肝硬化模型中细胞周期相关蛋白的表达模式
J Gastroenterol. 2001 Jan;36(1):24-32. doi: 10.1007/s005350170150.
6
Effects of zedoary turmeric oil on P450 activities in rats with liver cirrhosis induced by thioacetamide.莪术油对硫代乙酰胺诱导的肝硬化大鼠P450活性的影响。
Int J Clin Exp Pathol. 2014 Oct 15;7(11):7854-62. eCollection 2014.
7
[Protein expression profiles in a rat cirrhotic model induced by thioacetamide].[硫代乙酰胺诱导的大鼠肝硬化模型中的蛋白质表达谱]
Korean J Hepatol. 2006 Mar;12(1):93-102.
8
Cytochrome P450 dysregulations in thioacetamide-induced liver cirrhosis in rats and the counteracting effects of hepatoprotective agents.硫代乙酰胺诱导的大鼠肝硬化中细胞色素 P450 的失调及其肝保护剂的拮抗作用。
Drug Metab Dispos. 2012 Apr;40(4):796-802. doi: 10.1124/dmd.111.043539. Epub 2012 Jan 20.
9
Hepatoprotective Effects of Traditional Chinese Medicine on Liver Fibrosis from Ethanol Administration following Partial Hepatectomy.中药对部分肝切除术后乙醇给药所致肝纤维化的肝保护作用。
Chin J Physiol. 2015 Dec 31;58(6):393-403. doi: 10.4077/CJP.2015.BAD339.
10
Hesperidin a flavanoglycone protects against gamma-irradiation induced hepatocellular damage and oxidative stress in Sprague-Dawley rats.橙皮苷，一种黄烷糖苷，可保护斯普拉格-道利大鼠免受γ射线诱导的肝细胞损伤和氧化应激。
Eur J Pharmacol. 2008 Jun 10;587(1-3):273-80. doi: 10.1016/j.ejphar.2008.03.052. Epub 2008 Apr 4.

引用本文的文献

1
Gamma-Glutamyltransferase Activity (GGT) Is a Long-Sought Biomarker of Redox Status in Blood Circulation: A Retrospective Clinical Study of 44 Types of Human Diseases.谷氨酰转移酶活性（GGT）是血液中氧化还原状态的长期寻求的生物标志物：44 种人类疾病的回顾性临床研究。
Oxid Med Cell Longev. 2022 Jun 6;2022:8494076. doi: 10.1155/2022/8494076. eCollection 2022.
2
Studies on the Antiliver Injury of Effective Parts from by Rats and Mice Model .基于大鼠和小鼠模型对[具体药物名称]有效部位抗肝损伤的研究 。（你提供的原文中“by Rats and Mice Model”前缺少具体药物或物质，这里补充了“[具体药物名称]”使句子更完整通顺）
Evid Based Complement Alternat Med. 2022 Apr 26;2022:7821724. doi: 10.1155/2022/7821724. eCollection 2022.
3

本文引用的文献

1
Autophagic effects of Chaihu (dried roots of Bupleurum Chinense DC or Bupleurum scorzoneraefolium WILD).柴胡（北柴胡或狭叶柴胡的干燥根）的自噬作用。
Chin Med. 2014 Sep 11;9:21. doi: 10.1186/1749-8546-9-21. eCollection 2014.
2
Ligustrum lucidum Ait. fruit extract induces apoptosis and cell senescence in human hepatocellular carcinoma cells through upregulation of p21.女贞子果实提取物通过上调p21诱导人肝癌细胞凋亡和细胞衰老。
Oncol Rep. 2014 Sep;32(3):1037-42. doi: 10.3892/or.2014.3312. Epub 2014 Jul 7.
3
Chrysanthemum morifolium extract attenuates high-fat milk-induced fatty liver through peroxisome proliferator-activated receptor α-mediated mechanism in mice.
The efficient biogeneration of Ag and NiO nanoparticles from VPLE and a study of the anti-diabetic properties of the extract.
利用VPLE高效生物合成银和氧化镍纳米颗粒及其提取物抗糖尿病特性的研究
RSC Adv. 2020 Jan 16;10(5):3005-3012. doi: 10.1039/c9ra08668d. eCollection 2020 Jan 14.
4
Tartary buckwheat extract alleviates alcohol-induced acute and chronic liver injuries through the inhibition of oxidative stress and mitochondrial cell death pathway.苦荞提取物通过抑制氧化应激和线粒体细胞死亡途径减轻酒精诱导的急性和慢性肝损伤。
Am J Transl Res. 2020 Jan 15;12(1):70-89. eCollection 2020.
菊花提取物通过过氧化物酶体增殖物激活受体α介导的机制减轻高脂乳诱导的小鼠脂肪肝。
Nutr Res. 2014 Mar;34(3):268-75. doi: 10.1016/j.nutres.2013.12.010. Epub 2014 Jan 7.
4
Artemisia scoparia extract attenuates non-alcoholic fatty liver disease in diet-induced obesity mice by enhancing hepatic insulin and AMPK signaling independently of FGF21 pathway.青蒿提取物通过增强肝胰岛素和 AMPK 信号通路而不依赖于 FGF21 途径来减轻饮食诱导肥胖小鼠的非酒精性脂肪肝病。
Metabolism. 2013 Sep;62(9):1239-49. doi: 10.1016/j.metabol.2013.03.004. Epub 2013 May 21.
5
Gardenia jasminoides attenuates hepatocellular injury and fibrosis in bile duct-ligated rats and human hepatic stellate cells.栀子减轻胆管结扎大鼠和人肝星状细胞的肝细胞损伤和纤维化。
World J Gastroenterol. 2012 Dec 28;18(48):7158-65. doi: 10.3748/wjg.v18.i48.7158.
6
Reversibility of liver fibrosis.肝纤维化的可逆性
Fibrogenesis Tissue Repair. 2012 Jun 6;5(Suppl 1):S26. doi: 10.1186/1755-1536-5-S1-S26. eCollection 2012.
7
Dietary administration of berberine or Phellodendron amurense extract inhibits cell cycle progression and lung tumorigenesis.饮食中添加小檗碱或黄柏提取物可抑制细胞周期进程并抑制肺癌发生。
Mol Carcinog. 2011 Jan;50(1):1-7. doi: 10.1002/mc.20690.
8
Hepatoprotective effects of berberine on carbon tetrachloride-induced acute hepatotoxicity in rats.小檗碱对四氯化碳诱导的大鼠急性肝毒性的保护作用。
Chin Med. 2010 Sep 18;5:33. doi: 10.1186/1749-8546-5-33.
9
Evaluation of aqueous extracts of Taraxacum officinale on growth and invasion of breast and prostate cancer cells.蒲公英水提取物对乳腺癌和前列腺癌细胞生长及侵袭的评估。
Int J Oncol. 2008 May;32(5):1085-90.
10
Herb medicine Yin-Chen-Hao-Tang ameliorates hepatic fibrosis in bile duct ligation rats.中药茵陈蒿汤改善胆管结扎大鼠的肝纤维化。
J Ethnopharmacol. 2007 Jan 19;109(2):318-24. doi: 10.1016/j.jep.2006.07.042. Epub 2006 Aug 5.