Gao Hongying, Tayebee Reza, Abdizadeh Mojtaba Fattahi, Mansouri Esrafil, Latifnia Maryam, Pourmojahed Zahra
Department of Chinese Medicine, Binzhou City Central Hospital Binzhou Shandong Province 251700 China.
Department of Chemistry, School of Sciences, Hakim Sabzevari University Sabzevar 96179-76487 Iran
RSC Adv. 2020 Jan 16;10(5):3005-3012. doi: 10.1039/c9ra08668d. eCollection 2020 Jan 14.
leaf extract (VPLE) is used to mediate the green biosynthesis of Ag and NiO nanoparticles in aqueous solutions under mild conditions. The synthesized nanoparticles, with a narrow size range and good distribution, are characterized by means of powder X-ray diffraction (PXRD), Fourier-transform infrared (FT-IR), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), and transmission electron microscopy (TEM) techniques. SEM and TEM micrographs proved formation of mostly spherical or ellipsoidal nanoparticles with little agglomeration, and the average particle size was less than 20-35 nm for both types of nanoparticle. Then, the protective role of VPLE toward the liver is assessed in streptozotocin-induced diabetic rats. For this purpose, diabetes is induced in rats through the intraperitoneal injection of streptozotocin, and VPLE is administered oral gavage for 6 weeks. This study suggests that VPLE can ameliorate biochemical and structural changes in the livers of diabetic rats, showing that VPLE can improve the condition of rats with diabetic hepatopathy a decrease in oxidative stress and an enhancement in the activity of antioxidant enzymes in the liver.
叶提取物（VPLE）用于在温和条件下介导水溶液中银和氧化镍纳米颗粒的绿色生物合成。合成的纳米颗粒尺寸范围窄且分布良好，通过粉末X射线衍射（PXRD）、傅里叶变换红外光谱（FT-IR）、扫描电子显微镜（SEM）、能量色散X射线光谱（EDX）和透射电子显微镜（TEM）技术进行表征。SEM和TEM显微照片证明形成了大多为球形或椭圆形的纳米颗粒，团聚较少，两种类型的纳米颗粒平均粒径均小于20 - 35nm。然后，在链脲佐菌素诱导的糖尿病大鼠中评估VPLE对肝脏的保护作用。为此，通过腹腔注射链脲佐菌素诱导大鼠患糖尿病，并通过口服灌胃给予VPLE 6周。本研究表明，VPLE可改善糖尿病大鼠肝脏的生化和结构变化，表明VPLE可改善糖尿病性肝病大鼠的状况，降低氧化应激并增强肝脏中抗氧化酶的活性。
