Lino-Silva Leonardo Saúl, Salcedo-Hernández Rosa A, Ruiz-García Erika B, León-Takahashi Alberto M, García-Pérez Leticia
Gastrointestinal Pathology, Instituto Nacional de Cancerología (INCan), Mexico City, Mexico.
Surgical Oncology, Instituto Nacional de Cancerología (INCan), Mexico City, Mexico.
J Gastrointest Oncol. 2017 Feb;8(1):96-101. doi: 10.21037/jgo.2016.09.04.
There is an increase in the incidence of rectal carcinoma (RC) in young patients.
We analyzed 175 patients with sporadic RC which were divided in two groups according their age: 24 patients ≤40 years and 151 patients >40 years and the two groups were compared in order to determine if the outcomes (especially overall 5-year survival) were different.
Overall 5-year survival was similar between groups (67.1% for patients over 40 years and 70.4% for those under 40 years, P=0.803). The only differences found were in some clinicopathologic features: patients <40 years showed more dissected lymph nodes (LNs) (21 . 15, P=0.035) and more LN metastasis (54.2% . 39.1%, P=0.048). In multivariate analysis factors associated with worse survival were incomplete resection and no use of neoadjuvant therapy. Age did not demonstrate prognostic value (P=0.077).
RC in people ≤40 years demonstrated greater number of LN harvested and LN metastases but oncologic outcomes, especially 5-year overall survival, were similar between groups.
年轻患者中直肠癌（RC）的发病率有所上升。
我们分析了175例散发性直肠癌患者，根据年龄将其分为两组：24例年龄≤40岁，151例年龄>40岁，比较两组以确定预后（尤其是5年总生存率）是否不同。
两组的5年总生存率相似（40岁以上患者为67.1%，40岁以下患者为70.4%，P = 0.803）。发现的唯一差异在于一些临床病理特征：40岁以下患者的清扫淋巴结（LNs）更多（21.15，P = 0.035），且淋巴结转移更多（54.2%.39.1%，P = 0.048）。多因素分析显示，与较差生存率相关的因素是切除不完全和未使用新辅助治疗。年龄未显示出预后价值（P = 0.077）。
40岁及以下人群的直肠癌显示出更多的淋巴结清扫和淋巴结转移，但两组间的肿瘤学预后，尤其是5年总生存率相似。
