Jamshidi Shokoofeh, Zargaran Massoumeh, Roshanaei Ghodratollah, Hadadi Fatemeh, Dehghani Nazhvani Ali
Dental Research Center, Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran.
Dept. of Biostatistics, Hamadan University of Medical Sciences & Health Services, Hamadan, Iran.
J Dent (Shiraz). 2017 Mar;18(1):43-46.
Odontogenic keratocyst (OKC) is a developmental odontogenic cyst with specific histopathological features, high recurrence rate, and aggressive clinical behavior. Angiogenesis might be considered as an important factor for the growth, expansion, and distribution of this lesion.
The aim of the present study was to determine the mean vascular densities (MVD) of OKCs and dentigerous cysts to evaluate their relationship with the biologic behavior of these lesions.
In this cross-sectional analytical study, angiogenesis was assessed in OKC and dentigerous cyst by measuring the MVD. Immunohistochemistry was carried out using CD34 and CD105. The results were analyzed with independent samples t-test. The data were analyzed, setting value at 0.05.
The MVDs with the use of CD34 and CD105 markers were significantly higher in OKC compared to dentigerous cyst (< 0.05). In addition, MVDs obtained by CD105 in dentigerous cysts and OKC were significantly less than those based on CD34 (< 0.05).
Based on the results of the present study, it can be suggested that angiogenesis might be one of the possible mechanisms involved in higher aggressive biologic behavior and greater recurrence rate of OKC compared to dentigerous cysts.
牙源性角化囊肿（OKC）是一种具有特定组织病理学特征、高复发率和侵袭性临床行为的发育性牙源性囊肿。血管生成可能被认为是该病变生长、扩展和分布的一个重要因素。
本研究的目的是确定OKC和含牙囊肿的平均血管密度（MVD），以评估它们与这些病变生物学行为的关系。
在这项横断面分析研究中，通过测量MVD评估OKC和含牙囊肿中的血管生成。使用CD34和CD105进行免疫组织化学检测。结果采用独立样本t检验进行分析。数据进行分析，设定P值为0.05。
与含牙囊肿相比，OKC中使用CD34和CD105标记物的MVD显著更高（P<0.05）。此外，含牙囊肿和OKC中由CD105获得的MVD显著低于基于CD34的MVD（P<0.05）。
基于本研究结果，可以认为血管生成可能是OKC比含牙囊肿具有更高侵袭性生物学行为和更高复发率的可能机制之一。
