Tokudome S, Ikeda M, Matsushita K, Maeda Y, Yoshinari M
Department of Community Health Science, Saga Medical School, Japan.
Hepatogastroenterology. 1987 Dec;34(6):246-8.
In order to examine the association between hepatitis B virus carriage and hepatocellular carcinoma 3,769 female hepatitis B surface antigen positive blood donors were followed-up from 1977 to 1985 in Fukuoka, Japan. The observed number of deaths was compared with the expected deaths calculated by applying cause- and age-specific death rates among females for Fukuoka in 1980 to age-specific population at risk of the subjects. Mortalities from all causes and from all malignant neoplasms were decreased. Mortality from liver cancer (or hepatocellular carcinoma) was specifically elevated as compared with the general population; where observed, expected deaths, and O/E were 4, 0.71, and 5.63, respectively (p less than 0.05). Population attributable risk was estimated to be 6.5%. These values were assumed to be somewhat underestimated, in part because of a healthy donor effect and limited observation period.
为了研究乙肝病毒携带与肝细胞癌之间的关联，1977年至1985年期间，对日本福冈市3769名乙肝表面抗原阳性的女性献血者进行了随访。将观察到的死亡人数与通过应用1980年福冈市女性特定病因和年龄别死亡率到研究对象的年龄别危险人群中计算出的预期死亡人数进行比较。所有原因和所有恶性肿瘤的死亡率均有所下降。与普通人群相比，肝癌（或肝细胞癌）的死亡率显著升高；观察到的死亡人数、预期死亡人数和观察到的死亡人数与预期死亡人数之比（O/E）分别为4、0.71和5.63（p<0.05）。人群归因风险估计为6.5%。这些数值被认为在一定程度上被低估了，部分原因是存在健康献血者效应和观察期有限。
