人类结肠癌中I类HLA基因的改变。
Alterations of class I HLA genes in human colon cancers.
作者信息
Bar-Eli M, Battifora H, Cline M J
机构信息
Department of Microbiology and Immunology, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel.
出版信息
Hum Genet. 1988 Jan;78(1):86-9. doi: 10.1007/BF00291242.
Alterations of HLA class I genes were found in 3 of 12 human colon cancers. Rearrangements in HLA class I genes were observed in 2 cancers and amplification of HLA-coding genes was observed in 1 cancer. All 3 cancers were at an advanced stage. No examples of amplification or rearrangement in the HLA genes were found in 10 other tumours of diverse types. No alterations in the beta 2-microglobulin gene were observed in 22 human solid tumours included in this study. The association between alterations in HLA genes and proto-oncogenes in these tumours is discussed.
在12例人类结肠癌中，有3例发现了HLA I类基因改变。在2例癌症中观察到HLA I类基因重排，在1例癌症中观察到HLA编码基因扩增。所有3例癌症均处于晚期。在其他10种不同类型的肿瘤中未发现HLA基因扩增或重排的例子。在本研究纳入的22例人类实体瘤中，未观察到β2-微球蛋白基因改变。本文讨论了这些肿瘤中HLA基因改变与原癌基因之间的关联。
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