Iskandar Irene, Setiawan Finna, Sasongko Lucy D N, Adnyana I Ketut
Pharmacology and Clinical Pharmacy Research Group, School of Pharmacy, Institut Teknologi Bandung, Bandung 40132, Indonesia.
Faculty of Pharmacy, University of Surabaya, Surabaya 60293, Indonesia.
Sci Pharm. 2017 Mar 8;85(1):10. doi: 10.3390/scipharm85010010.
Tamarind water extract has been shown to demonstrate an anti-obesity effect. In this research, long-term use of tamarind pulp water extract safety was evaluated. Tamarind pulp was extracted by reflux method, followed by freeze-drying to obtain dry extract. Wistar rats were divided into six groups, with 20 animals of each sex per group. The control group and satellite control group received carboxymethylcellulose sodium (CMC-Na) 0.5% 1 mL/100 g bw (body weight) per day. Treatment groups received tamarind pulp extract at doses of 75, 200, 1000, satellite 1000 mg/kg bw per day for six months. After six months, control groups and the treatment group were sacrificed. Satellite groups were sacrificed one month later. Relative organ weights, hematology and clinical biochemistry profiles were determined. After six months, there were no significant change in body weight, hematologic, and clinical biochemistry profiles of the tested group. Body weight of male rats in the satellite 1000 mg/kg bw group was significantly increased in week 30 compared to the satellite control group ( < 0.05). The relative spleen weight of female rats of the 200 mg/kg bw group was reduced ( < 0.05). The relative kidney weight of male rats in the 1000 mg/kg bw group was increased ( < 0.05). This study showed that tamarind pulp extract was generally safe and well tolerated at the tested dose.
罗望子水提取物已被证明具有抗肥胖作用。在本研究中，对罗望子果肉水提取物的长期使用安全性进行了评估。罗望子果肉采用回流法提取，然后冷冻干燥以获得干提取物。将Wistar大鼠分为六组，每组每种性别各20只动物。对照组和卫星对照组每天接受0.5%羧甲基纤维素钠（CMC-Na）1 mL/100 g体重（bw）。治疗组每天按75、200、1000、卫星1000 mg/kg bw的剂量接受罗望子果肉提取物，持续六个月。六个月后，处死对照组和治疗组。卫星组一个月后处死。测定相对器官重量、血液学和临床生化指标。六个月后，试验组的体重、血液学和临床生化指标无显著变化。与卫星对照组相比，卫星1000 mg/kg bw组雄性大鼠在第30周时体重显著增加（<0.05）。200 mg/kg bw组雌性大鼠的相对脾脏重量降低（<0.05）。1000 mg/kg bw组雄性大鼠的相对肾脏重量增加（<0.05）。本研究表明，罗望子果肉提取物在试验剂量下总体安全且耐受性良好。
