Escalona-Arranz J C, Perez-Rosés R, Rodríguez-Amado J, Morris-Quevedo H J, Mwasi L B, Cabrera-Sotomayor O, Machado-García R, Fong-Lórez O, Alfonso-Castillo A, Puente-Zapata E
a Department of Pharmacy , Oriente University , Avenida Patricio Lumumba s/n, 90500 Santiago de Cuba , Cuba.
b Departament Farmacología i Química Terapéutica , Universitat de Barcelona , Barcelona , Spain.
Nat Prod Res. 2016;30(4):456-9. doi: 10.1080/14786419.2015.1019350. Epub 2015 Mar 10.
In the scientific community, there is a growing interest in Tamarindus indica L. leaves, both as a valuable nutrient and as a functional food. This paper focuses on exploring its safety and antioxidant properties. A tamarind leaf fluid extract (TFE) wholly characterised was evaluated for its anti-DPPH activity (IC50 = 44.36 μg/mL) and its reducing power activity (IC50 = 60.87 μg/mL). TFE also exhibited a high ferrous ion-chelating capacity, with an estimated binding constant of 1.085 mol L(-1) while its influence over nitric oxide production in human leucocytes was irregular. At low concentrations, TFE stimulated NO output, but it significantly inhibited it when there was an increase in concentration. TFE was also classified as a non-toxic substance in two toxicity tests: the acute oral toxicity test and the oral mucous irritability test. Further toxicological assays are needed, although results so far suggest that TFE might become a functional dietary supplement.
在科学界，人们对罗望子叶作为一种有价值的营养物质和功能性食品的兴趣与日俱增。本文着重探讨其安全性和抗氧化特性。对一种完全表征的罗望子叶流体提取物（TFE）进行了抗DPPH活性（IC50 = 44.36 μg/mL）和还原能力活性（IC50 = 60.87 μg/mL）的评估。TFE还表现出较高的亚铁离子螯合能力，估计结合常数为1.085 mol L(-1)，而其对人白细胞中一氧化氮产生的影响并不规律。在低浓度时，TFE刺激一氧化氮的产生，但当浓度增加时，它会显著抑制一氧化氮的产生。在急性经口毒性试验和口腔黏膜刺激性试验这两项毒性试验中，TFE也被归类为无毒物质。尽管目前的结果表明TFE可能会成为一种功能性膳食补充剂，但仍需要进一步的毒理学分析。
