枯草芽孢杆菌中缺乏产生二肽抗生素杆菌溶素能力的突变体：突变的分离与定位
Bacillus subtilis mutant deficient in the ability to produce the dipeptide antibiotic bacilysin: isolation and mapping of the mutation.
作者信息
Hilton M D, Alaeddinoglu N G, Demain A L
机构信息
Department of Applied Biological Sciences, Massachusetts Institute of Technology, Cambridge 02139.
出版信息
J Bacteriol. 1988 Feb;170(2):1018-20. doi: 10.1128/jb.170.2.1018-1020.1988.
Abstract
A Bacillus subtilis mutant which carries a lesion in a gene specific to the synthesis of the dipeptide antibiotic bacilysin was isolated. A derivative strain in which transposon Tn917 had inserted near the bacilysin lesion was isolated and used as the donor in PBS-1 transduction mapping experiments. The bac-1 locus was mapped between the ctrA and sacA loci, near 90% on the standard B. subtilis 168 chromosome map.
摘要
分离出一株枯草芽孢杆菌突变体，该突变体在二肽抗生素杆菌溶素合成的一个特定基因中存在损伤。分离出一个转座子Tn917插入到杆菌溶素损伤附近的衍生菌株，并将其用作PBS-1转导定位实验的供体。bac-1位点被定位在ctrA和sacA位点之间，在标准枯草芽孢杆菌168染色体图谱上接近90%的位置。
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