卡波西肉瘤相关疱疹病毒对致癌信号网络的调控
Modulation of oncogenic signaling networks by Kaposi's sarcoma-associated herpesvirus.
作者信息
Wong Jason P, Damania Blossom
机构信息
.
出版信息
Biol Chem. 2017 Jul 26;398(8):911-918. doi: 10.1515/hsz-2017-0101.
Abstract
Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiological agent of three human malignancies: Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. To persist and replicate within host cells, KSHV encodes proteins that modulate different signaling pathways. Manipulation of cell survival and proliferative networks by KSHV can promote the development of KSHV-associated malignancies. In this review, we discuss recent updates on KSHV pathogenesis and the viral life cycle. We focus on proteins encoded by KSHV that modulate the phosphatidylinositol-4,5-bisphosphate 3 kinase and extracellular signal-regulated kinases 1/2 pathways to create an environment favorable for viral replication and the development of KSHV malignancies.
摘要
卡波西肉瘤相关疱疹病毒（KSHV）是三种人类恶性肿瘤的病原体：卡波西肉瘤、原发性渗出性淋巴瘤和多中心性Castleman病。为了在宿主细胞内持续存在并复制，KSHV编码调节不同信号通路的蛋白质。KSHV对细胞存活和增殖网络的操控可促进KSHV相关恶性肿瘤的发展。在本综述中，我们讨论了KSHV发病机制和病毒生命周期的最新进展。我们重点关注KSHV编码的蛋白质，这些蛋白质调节磷脂酰肌醇-4,5-二磷酸3激酶和细胞外信号调节激酶1/2通路，以创造有利于病毒复制和KSHV恶性肿瘤发展的环境。
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