Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Nat Rev Microbiol. 2018 Nov;16(11):684-698. doi: 10.1038/s41579-018-0064-6.
Viral infection is a major contributor to the global cancer burden. Recent advances have revealed that seven known oncogenic viruses promote tumorigenesis through shared host cell targets and pathways. A comprehensive understanding of the principles of viral oncogenesis may enable the identification of unknown infectious aetiologies of cancer and the development of therapeutic or preventive strategies for virus-associated cancers. In this Review, we discuss the molecular mechanisms of viral oncogenesis in humans. We highlight recent advances in understanding how viral manipulation of host cellular signalling, DNA damage responses, immunity and microRNA targets promotes the initiation and development of cancer.
病毒感染是全球癌症负担的主要因素之一。最近的进展表明，七种已知的致癌病毒通过共享的宿主细胞靶标和途径促进肿瘤发生。全面了解病毒致癌的原理可能有助于确定癌症未知的传染性病因，并为病毒相关性癌症开发治疗或预防策略。在这篇综述中，我们讨论了人类病毒致癌的分子机制。我们强调了最近在理解病毒如何操纵宿主细胞信号、DNA 损伤反应、免疫和 microRNA 靶标以促进癌症的发生和发展方面的进展。
