Uyterlinde A M, Schipper N W, Baak J P
Pathological Institute, Free University Hospital, Amsterdam, The Netherlands.
J Clin Pathol. 1987 Dec;40(12):1432-6. doi: 10.1136/jcp.40.12.1432.
In 65 patients with primary invasive ductal breast carcinoma the relation between classic prognosticators describing the extent of disease (lymph node metastases and tumour size) and newer promising morphometric and DNA flow cytometric prognostic factors was studied. There was no relation between DNA ploidy, lymph node state, and tumour size. Tumours with a mitotic activity index of more than 10 were predominantly DNA aneuploid (61%) compared with those with a mitotic activity index of less than 10 which showed a DNA aneuploid pattern in 27%. The strongest prognosticator, the morphometric prognostic index (a multivariate combination of mitotic activity index, tumour size, and lymph node state) correlated positively with the DNA index in 63% of the cases (p = 0.038). Thus there was a discrepancy between the morphometric and DNA flow cytometric prognostic variables in 37% of the cases. These results indicate that morphometric and flow cytometric analysis may provide additional information on the prognosis in primary breast cancer.
在65例原发性浸润性导管乳腺癌患者中，研究了描述疾病范围的经典预后因素（淋巴结转移和肿瘤大小）与新出现的有前景的形态计量学和DNA流式细胞术预后因素之间的关系。DNA倍体、淋巴结状态和肿瘤大小之间没有关系。有丝分裂活性指数大于10的肿瘤主要为DNA非整倍体（61%），而有丝分裂活性指数小于10的肿瘤显示DNA非整倍体模式的比例为27%。最强的预后因素，即形态计量学预后指数（有丝分裂活性指数、肿瘤大小和淋巴结状态的多变量组合）在63%的病例中与DNA指数呈正相关（p = 0.038）。因此，在37%的病例中，形态计量学和DNA流式细胞术预后变量之间存在差异。这些结果表明，形态计量学和流式细胞术分析可能为原发性乳腺癌的预后提供额外信息。
