Aamdal S, Børmer O, Jørgensen O, Høst H, Eliassen G, Kaalhus O, Pihl A
Cancer. 1984 Jun 1;53(11):2525-9. doi: 10.1002/1097-0142(19840601)53:11<2525::aid-cncr2820531126>3.0.co;2-8.
The long-term prognosis in 233 primary breast cancer patients, most of whom had received ovarian irradiation, has been related to the estrogen-receptor status of the primary tumors. The median observation time was 9 years. The receptor status did influence disease-free interval and survival only in patients having metastases in axillary nodes. Thus, in the postmenopausal patients with axillary metastases, the disease-free interval and survival time were longer in receptor-positive than in receptor-negative patients during the first few years of observation. However, this difference disappeared in the course of the subsequent years. In the premenopausal women with axillary metastases the receptor status did not influence the short-term prognosis, and, unexpectedly, seemed to affect adversely the long-term prognosis. It is concluded that the long-term prognosis is no better in breast cancer patients having estrogen receptors in their primary tumors than in those with receptor-negative tumors.
233例原发性乳腺癌患者的长期预后情况（其中大多数患者接受过卵巢放疗）与原发肿瘤的雌激素受体状态相关。中位观察时间为9年。仅在腋窝淋巴结有转移的患者中，受体状态才会影响无病间期和生存率。因此，在绝经后有腋窝转移的患者中，在观察的最初几年里，受体阳性患者的无病间期和生存时间比受体阴性患者更长。然而，这种差异在随后几年中消失了。在绝经前有腋窝转移的女性中，受体状态不影响短期预后，而且出乎意料的是，似乎对长期预后有不利影响。得出的结论是，原发性肿瘤有雌激素受体的乳腺癌患者的长期预后并不比受体阴性肿瘤患者更好。
