Baloch Zulqarnain, Yasmeen Nafeesa, Li Yuanyue, Ma Ke, Wu Xiaomei, Yang Shi-Hua, Xia Xueshan
College of Veterinary Medicine, South China Agricultural University, Tianhe District, Guangzhou, China.
University of Veterinary and Animal Sciences, Department of Microbiology, Lahore, Pakistan.
Braz J Infect Dis. 2017 May-Jun;21(3):325-332. doi: 10.1016/j.bjid.2017.01.009. Epub 2017 Mar 8.
Dai is a major Chinese ethnic minority group residing in rural areas of the southern part of Yunnan. However, no data exist on the Human Papillomavirus (HPV) prevalence and genotype distribution among Dai women.
A total of 793 participants (Dai=324, Han=251, other ethnic=218) were included in this study. PCR was performed to detect the HPV-positive samples, and genotyping was performed with an HPV Geno-Array.
The overall HPV prevalence was very low among Dai women compared to the others. The prevalence of high-risk-HPV infections was significantly higher (p=0.001) among other ethnic women (22.0%) than that among Han (13.1%) and Dai women (7.1%). The overall HPV, high-risk-HPV, single and multiple infection prevalence among rural women were 12.9%, 12.1%, 12.3%, and 0.5%, respectively. HPV-16 (5.5%) was shown to be the most prevalent genotype, followed by HPV-52 (2.6%) and HPV-58 (2.4%). Urban women had relatively higher rates of overall HPV (16.0%), high-risk-HPV (14.1%), single genotype (11.9%), and multiple genotype (4.1%) infections. In urban women, HPV-52 (3.6%) was the most prevalent genotype, followed by HPV-39 (2.7%) and HPV-16 (1.2%). In the urban area, HPV prevalence was highest in women aged <29 years, but declined with increasing age. However, in rural women, the highest HPV prevalence was observed among women at older age (>50 years). Education and smoking habit were significantly associated with HPV infection among both rural and urban area women (p<0.001).
The prevalence and genotype distribution of HPV varied among ethnic women in urban and rural area of Yunnan Province.
傣族是居住在云南省南部农村地区的主要中国少数民族群体。然而，目前尚无关于傣族女性人乳头瘤病毒（HPV）感染率及基因型分布的数据。
本研究共纳入793名参与者（傣族324名、汉族251名、其他民族218名）。采用聚合酶链反应（PCR）检测HPV阳性样本，并使用HPV基因芯片进行基因分型。
与其他民族女性相比，傣族女性的总体HPV感染率非常低。其他民族女性（22.0%）的高危型HPV感染率显著高于汉族（13.1%）和傣族女性（7.1%）（p = 0.001）。农村女性的总体HPV、高危型HPV、单一感染和多重感染率分别为12.9%、12.1%、12.3%和0.5%。HPV-16（5.5%）是最常见的基因型，其次是HPV-52（2.6%）和HPV-58（2.4%）。城市女性的总体HPV（16.0%）、高危型HPV（14.1%）、单一基因型（11.9%）和多重基因型（4.1%）感染率相对较高。在城市女性中，HPV-52（3.6%）是最常见的基因型，其次是HPV-39（2.7%）和HPV-16（1.2%）。在城市地区，HPV感染率在<29岁的女性中最高，但随年龄增长而下降。然而，在农村女性中，HPV感染率在年龄较大（>50岁）的女性中最高。教育程度和吸烟习惯与城乡女性的HPV感染均显著相关（p<0.001）。
云南省城乡不同民族女性的HPV感染率及基因型分布存在差异。
