Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Dali University, Dali, China.
Graduate School of Health Sciences, Hokkaido University, Sapporo, Hokkaido, Japan.
J Med Virol. 2019 Aug;91(8):1553-1561. doi: 10.1002/jmv.25477. Epub 2019 Apr 21.
Accumulating evidence indicates that persistent infection with high-risk oncogenic human papillomavirus (HPV) genotypes is the most important risk factor for cervical cancer, and that the distribution of HPV genotypes varies regionally. This study explored the prevalence and genotype distribution of HPV infection among Han, Yi, and Bai women in various regions of Dali Bai Autonomous Prefecture, Yunnan Province, China. This cross-sectional study included 2779 women (20-76 years old) who were referred for 21-HPV genotype array diagnostic from five regions of Dali Bai Autonomous Prefecture between February 2013 and May 2016. Statistical methods used included a the χ test, Fisher's exact test, t test, and logistic regression. Overall HPV prevalence in the study population was 7.6%. HPV-52, HPV-58, HPV-18, HPV-81, and HPV-16 were the most prevalent genotypes in the study area, and notably, the prevalence of HPV-58 was significantly higher among women in Heqing County than that in other regions. Univariate analysis showed that husband's age, region, fertility status, and parity were potential factors associated with HPV infection. Multivariate logistic regression analysis revealed that Heqing County was an independent risk factor for HPV infection among women in the Dali area, moreover, Yi women showed the highest risk for HPV infections. Overall, our finding emphasizing the urgent need for an HPV screening and prevention program in Heqing County and Yi women. We also suggest that HPV-related health education should be provided not only to women, but also to men, to reduce the risk of infection in women.
越来越多的证据表明，高危型人乳头瘤病毒（HPV）持续感染是宫颈癌最重要的危险因素，HPV 基因型的分布具有区域性差异。本研究旨在探讨中国云南省大理白族自治州不同地区汉族、彝族和白族妇女 HPV 感染的流行率及基因型分布。本横断面研究共纳入 2779 名（20-76 岁）于 2013 年 2 月至 2016 年 5 月期间来自大理白族自治州五个地区的妇女，她们因进行 21 型 HPV 基因芯片诊断而就诊。采用 χ 检验、Fisher 确切检验、t 检验和 logistic 回归进行统计学分析。研究人群中 HPV 总感染率为 7.6%。HPV-52、HPV-58、HPV-18、HPV-81 和 HPV-16 是本研究地区最常见的基因型，尤其是 HPV-58 在鹤庆县的流行率明显高于其他地区。单因素分析显示，丈夫年龄、地区、生育状况和产次是 HPV 感染的潜在相关因素。多因素 logistic 回归分析显示，鹤庆县是大理地区妇女 HPV 感染的独立危险因素，此外，彝族妇女 HPV 感染风险最高。总之，我们的研究结果强调了在鹤庆县和彝族妇女中开展 HPV 筛查和预防计划的紧迫性。我们还建议不仅要对女性，还要对男性进行 HPV 相关健康教育，以降低女性的感染风险。
