Shi Xin, Zhang Weihong, Yin Liya, Chilian William M, Krieger Jessica, Zhang Ping
Department of Integrative Medical Sciences, College of Medicine, Northeast Ohio Medical University, Rootstown, Ohio.
Department of Basic Medicine, School of Nursing, Zhengzhou University, Zhengzhou, Henan Province, PR China.
Transl Res. 2017 Jun;184:77-100. doi: 10.1016/j.trsl.2017.02.002. Epub 2017 Feb 21.
Vascular precursor cells include stem cells and progenitor cells giving rise to all mature cell types in the wall of blood vessels. When tissue injury occurs, local hypoxia and inflammation result in the generation of vasculogenic mediators which orchestrate migration of vascular precursor cells from their niche environment to the site of tissue injury. The intricate crosstalk among signaling pathways coordinates vascular precursor cell proliferation and differentiation during neovascularization. Establishment of normal blood perfusion plays an essential role in the effective repair of the injured tissue. In recent years, studies on molecular mechanisms underlying the regulation of vascular precursor cell function have achieved substantial progress, which promotes exploration of vascular precursor cell-based approaches to treat chronic wounds and ischemic diseases in vital organ systems. Verification of safety and establishment of specific guidelines for the clinical application of vascular precursor cell-based therapy remain major challenges in the field.
血管前体细胞包括干细胞和祖细胞，它们可分化为血管壁中的所有成熟细胞类型。当组织发生损伤时，局部缺氧和炎症会导致血管生成介质的产生，这些介质协调血管前体细胞从其龛位环境迁移至组织损伤部位。在新血管形成过程中，信号通路之间复杂的相互作用协调着血管前体细胞的增殖和分化。建立正常的血液灌注对有效修复受损组织起着至关重要的作用。近年来，关于血管前体细胞功能调控的分子机制研究取得了重大进展，这推动了基于血管前体细胞的方法在治疗重要器官系统慢性伤口和缺血性疾病方面的探索。验证基于血管前体细胞治疗的安全性并建立其临床应用的具体指南仍然是该领域的主要挑战。
