Favril Sophie, Abma Eline, Blasi Francesco, Stock Emmelie, Devriendt Nausikaa, Vanderperren Katrien, de Rooster Hilde
Small Animal Department, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Cancer Research Institute Ghent (CRIG), Ghent, Belgium.
Vet Rec. 2018 Sep 22;183(11):354. doi: 10.1136/vr.104851. Epub 2018 Apr 28.
One of the major challenges in surgical oncology is the intraoperative discrimination of tumoural versus healthy tissue. Until today, surgeons rely on visual inspection and palpation to define the tumoural margins during surgery and, unfortunately, for various cancer types, the local recurrence rate thus remains unacceptably high. Near-infrared (NIR) fluorescence imaging is an optical imaging technique that can provide real-time preoperative and intraoperative information after administration of a fluorescent probe that emits NIR light once exposed to a NIR light source. This technique is safe, cost-effective and technically easy. Several NIR fluorescent probes are currently studied for their ability to highlight neoplastic cells. In addition, NIR fluorescence imaging holds great promise for sentinel lymph node mapping. The aim of this manuscript is to provide a literature review of the current organic NIR fluorescent probes tested in the light of human oncology and to introduce fluorescence imaging as a valuable asset in veterinary oncology.
外科肿瘤学的主要挑战之一是术中区分肿瘤组织与健康组织。直到如今，外科医生在手术过程中仍依靠视觉检查和触诊来确定肿瘤边界，不幸的是，对于各种癌症类型而言，局部复发率仍然高得令人难以接受。近红外（NIR）荧光成像是一种光学成像技术，在给予一种荧光探针后，该探针一旦暴露于近红外光源就会发出近红外光，从而能够提供实时的术前和术中信息。这项技术安全、经济高效且操作简便。目前正在研究几种近红外荧光探针突出肿瘤细胞的能力。此外，近红外荧光成像在前哨淋巴结定位方面前景广阔。本文的目的是根据人类肿瘤学对当前测试的有机近红外荧光探针进行文献综述，并介绍荧光成像作为兽医肿瘤学中的一项宝贵资产。
