State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, China.
Department of Chemistry, Nanchang University, Nanchang, China.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2020 Sep;12(5):e1635. doi: 10.1002/wnan.1635. Epub 2020 Apr 15.
Surgical resection of solid tumors is currently the most efficient and preferred therapeutic strategy for treating cancer. Despite significant medical, technical, and scientific advances, the complete treatment of this lethal disease is still a challenging task. New imaging techniques and contrast agents are urgently needed to improve cytoreductive surgery and patient outcomes. Tumor-targeted probes are valuable for guiding a surgical resection of tumor from subjective judgments to visual inspection. Near-infrared (NIR) fluorescent imaging is a promising technology in preclinical and clinical tumor diagnosis and therapy. The rapid development in NIR fluorophores with improved optical properties, targeting strategies, and imaging devices has brought about prospective study of novel NIR nanomaterials for intraoperative tumor detection. In this review, we summarize the recent development in NIR-emitting organic fluorophores and cancer-targeting strategies that specifically target and accumulate in tumors for the molecular imaging of cancerous cells. We believe this technique utilizing new fluorescent probes with an intraoperative optical imaging capacity could provide a more sensitive and accurate method for cancer resection guidance, thereby resulting in better surgical outcomes. This article is categorized under: Diagnostic Tools > in vivo Nanodiagnostics and Imaging Nanotechnology Approaches to Biology > Nanoscale Systems in Biology.
手术切除实体肿瘤是目前治疗癌症最有效和首选的治疗策略。尽管在医学、技术和科学方面取得了重大进展，但要完全治愈这种致命疾病仍然是一项具有挑战性的任务。新的成像技术和对比剂迫切需要改善细胞减少手术和患者的治疗效果。肿瘤靶向探针对于指导肿瘤的手术切除从主观判断到视觉检查具有重要意义。近红外（NIR）荧光成像是一种很有前途的临床前和临床肿瘤诊断和治疗技术。具有改进的光学性能、靶向策略和成像设备的 NIR 荧光团的快速发展，为新型 NIR 纳米材料在术中肿瘤检测中的应用带来了有前景的研究。在这篇综述中，我们总结了 NIR 发射有机荧光团和癌症靶向策略的最新进展，这些策略特异性地靶向并在肿瘤中积累，用于癌症细胞的分子成像。我们相信，这种利用具有术中光学成像能力的新型荧光探针的技术，可以为癌症切除提供更敏感和准确的指导方法，从而获得更好的手术效果。本文属于诊断工具 > 体内纳米诊断和成像 纳米技术方法应用于生物学 > 生物学中的纳米级系统。
