Department of Biomedical & Molecular Sciences, Queen's University, Kingston, Ontario, Canada; Allergy Research Unit, Kingston General Hospital, Kingston, Ontario, Canada; Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada; Southern Ontario Centre for Atmospheric Aerosol Research, University of Toronto, Toronto, Ontario, Canada.
Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada; Southern Ontario Centre for Atmospheric Aerosol Research, University of Toronto, Toronto, Ontario, Canada; Air Quality Research Division, Environment and Climate Change Canada, Toronto, Ontario, Canada; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
Ann Allergy Asthma Immunol. 2017 Apr;118(4):465-473. doi: 10.1016/j.anai.2017.01.002. Epub 2017 Mar 8.
The Kingston Allergy Birth Cohort (KABC) is a prenatally recruited cohort initiated to study the developmental origins of allergic disease. Kingston General Hospital was chosen for recruitment because it serves a population with notable diversity in environmental exposures relevant to the emerging concept of the exposome.
To establish a profile of the KABC using the exposome framework and examine parentally reported respiratory symptoms to 2 years of age.
Data on phase 1 of the cohort (n = 560 deliveries) were compiled, and multivariate Cox proportional hazards regression models were used to determine associations with respiratory symptoms.
The KABC exhibits diversity within the 3 exposome domains of general external (socioeconomic status, rural or urban residence), specific external (cigarette smoke, breastfeeding, mold or dampness), and internal (respiratory health, gestational age), as well as significant associations between exposures from different domains. Significant associations emerged between parental reports of wheeze or cough without a cold and prenatal cigarette smoke exposure, mold or dampness in the home, and the use of air fresheners in the early-life home environment. Breastfeeding, older siblings, and increased gestational age were associated with decreased respiratory symptoms.
The KABC is a unique cohort with diversity that can be leveraged for exposomics-based studies. This study found that all 3 domains of the exposome had effects on the respiratory health of KABC children. Ongoing studies using phase 1 of the KABC continue to explore the internal exposome through allergy skin testing and epigenetic analyses and the specific external domain through in-home environmental analyses, air pollution modeling, and ultimately potential convergences within and among domains.
金斯敦过敏出生队列（KABC）是一个在产前招募的队列，旨在研究过敏疾病的发育起源。金斯敦综合医院之所以被选中进行招募，是因为它服务的人群在与新兴的暴露组学概念相关的环境暴露方面具有显著的多样性。
利用暴露组学框架建立 KABC 概况，并研究父母报告的 2 岁以下儿童呼吸症状。
编译了队列的第 1 阶段（n=560 例分娩）的数据，并使用多变量 Cox 比例风险回归模型来确定与呼吸症状的关联。
KABC 在一般外部（社会经济地位、农村或城市居住）、特定外部（吸烟、母乳喂养、霉菌或潮湿）和内部（呼吸健康、胎龄）暴露组学的 3 个领域内表现出多样性，以及来自不同领域的暴露之间存在显著关联。父母报告的无感冒的喘息或咳嗽与产前吸烟暴露、家中的霉菌或潮湿以及在早期家庭环境中使用空气清新剂之间存在显著关联。母乳喂养、有兄弟姐妹和增加的胎龄与呼吸症状减少相关。
KABC 是一个具有多样性的独特队列，可以利用基于暴露组学的研究。本研究发现，暴露组学的所有 3 个领域都对 KABC 儿童的呼吸健康产生影响。正在使用 KABC 第 1 阶段的正在进行的研究继续通过过敏皮肤测试和表观遗传分析探索内部暴露组学，并通过家庭内环境分析、空气污染建模，最终在各领域内和各领域之间探索潜在的趋同。
