Xu Qian, Huff Lauren P, Fujii Masakazu, Griendling Kathy K
Division of Cardiology, Department of Medicine, Emory University, 101 Woodruff Circle, 308a WMB, Atlanta, GA 30322, United States; Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha, China.
Division of Cardiology, Department of Medicine, Emory University, 101 Woodruff Circle, 308a WMB, Atlanta, GA 30322, United States.
Free Radic Biol Med. 2017 Aug;109:84-107. doi: 10.1016/j.freeradbiomed.2017.03.004. Epub 2017 Mar 8.
The actin cytoskeleton is critical for form and function of vascular cells, serving mechanical, organizational and signaling roles. Because many cytoskeletal proteins are sensitive to reactive oxygen species, redox regulation has emerged as a pivotal modulator of the actin cytoskeleton and its associated proteins. Here, we summarize work implicating oxidants in altering actin cytoskeletal proteins and focus on how these alterations affect cell migration, proliferation and contraction of vascular cells. Finally, we discuss the role of oxidative modification of the actin cytoskeleton in vivo and highlight its importance for vascular diseases.
肌动蛋白细胞骨架对于血管细胞的形态和功能至关重要，具有机械、组织和信号传导作用。由于许多细胞骨架蛋白对活性氧敏感，氧化还原调节已成为肌动蛋白细胞骨架及其相关蛋白的关键调节因子。在这里，我们总结了有关氧化剂改变肌动蛋白细胞骨架蛋白的研究工作，并重点关注这些改变如何影响血管细胞的迁移、增殖和收缩。最后，我们讨论了肌动蛋白细胞骨架氧化修饰在体内的作用，并强调其对血管疾病的重要性。
