人多瘤病毒BK早期区域DNA对11号染色体短臂存在缺失的人成纤维细胞的形态学转化作用

Morphological transformation by early region human polyomavirus BK DNA of human fibroblasts with deletions in the short arm of one chromosome 11.

作者信息

de Ronde A, Mannens M, Slater R M, Hoovers J, Heyting C, Bleeker-Wagemakers E M, Leschot N J, van Strien A, Sol C J, ter Schegget J

机构信息

Department of Virology, University of Amsterdam, The Netherlands.

出版信息

J Gen Virol. 1988 Feb;69 ( Pt 2):467-71. doi: 10.1099/0022-1317-69-2-467.

DOI:10.1099/0022-1317-69-2-467

PMID:2828520

Abstract

Human fibroblasts derived from four individuals with various deletions in the short arm of one chromosome 11 were susceptible to morphological transformation by early region BK virus DNA, whereas diploid human fibroblasts were not. This difference in susceptibility to transformation by early region BK virus DNA might be explained by a putative 'transformation suppressor' locus situated within the deleted region on the short arm of chromosome 11.

摘要

从4名11号染色体短臂存在不同缺失的个体身上获取的人成纤维细胞，对BK病毒早期区域DNA介导的形态转化敏感，而二倍体人成纤维细胞则不敏感。对BK病毒早期区域DNA介导的转化敏感性存在差异，可能是由于11号染色体短臂缺失区域内假定的“转化抑制”基因座所致。