BK病毒DNA：一种人类肿瘤病毒的完整核苷酸序列

BK virus DNA: complete nucleotide sequence of a human tumor virus.

作者信息

Yang R C, Wu R

出版信息

Science. 1979 Oct 26;206(4417):456-62. doi: 10.1126/science.228391.

Abstract

The complete DNA sequence of the human papovavirus BK is presented. From the 4963 base-pair sequence of BK virus (MM strain), the amino acid sequence of at least five proteins can be deduced: a T antigen and a t antigen, which share amino terminal peptides; proteins VP2 and VP3, which share 232 amino acids; and protein VP1, whose coding sequence overlaps those for VP2 and VP3 by 113 nucleotides but is read in a different frame. The gene loci and the arrangement of genes are strikingly similar in BK virus and simian virus 40 (SV40). The sequence of the deduced proteins in BK virus shares 73 percent amino acid homology with those in SV40, whereas the DNA sequence of the two viruses shares 70 percent homology, suggesting close evolutionary relationship. However, the repeated DNA sequences in the noncoding regions of these viruses are different.

摘要

本文呈现了人乳头多瘤空泡病毒BK的完整DNA序列。从BK病毒（MM株）的4963个碱基对序列中，可以推导出至少五种蛋白质的氨基酸序列：一种T抗原和一种t抗原，它们共享氨基末端肽；VP2和VP3蛋白，它们共享232个氨基酸；以及VP1蛋白，其编码序列与VP2和VP3的编码序列有113个核苷酸重叠，但阅读框不同。BK病毒和猴病毒40（SV40）的基因位点和基因排列极为相似。BK病毒中推导的蛋白质序列与SV40中的蛋白质序列有73%的氨基酸同源性，而这两种病毒的DNA序列有70%的同源性，表明它们有密切的进化关系。然而，这些病毒非编码区的重复DNA序列是不同的。