Max Planck UCL Centre for Computational Psychiatry and Ageing Research, London, UK.
Curr Top Behav Neurosci. 2021;49:97-124. doi: 10.1007/7854_2020_197.
In this chapter, I address the concept of endophenotypes for obsessive-compulsive disorder (OCD). Endophenotypes are objective and heritable quantitative traits hypothesized to be more biologically tractable than distal clinical phenotypes. This approach has been adopted to gain a better understanding of psychiatric conditions in general. It is theorized that endophenotypes will particularly assist in clarifying both the diagnostic status and aetiological origins of complex neuropsychiatric conditions such as OCD. At the cognitive level, separable constructs of relevance for OCD have been identified. The prevailing model for OCD assumes the development of abnormalities within fronto-striatal neural circuits leading to impairment of executive functions and their neuropsychological subcomponents. Here, I address whether this model can guide towards the identification of endophenotypes for this condition and discuss possible implications.
在这一章中，我将讨论强迫症（OCD）的内表型概念。内表型是假设比远端临床表型更具有生物学可操作性的客观和可遗传的定量特征。这种方法被采用是为了更好地理解一般的精神疾病。据推测，内表型将特别有助于澄清 OCD 等复杂神经精神疾病的诊断状况和病因起源。在认知层面上，已经确定了与 OCD 相关的可分离结构。OCD 的流行模型假设额纹体神经回路中出现异常，导致执行功能及其神经心理学子成分受损。在这里，我将讨论该模型是否可以指导 OCD 内表型的识别，并讨论可能的影响。
