Linehan Eimear, Brennan Marian, O'Rourke Sadhbh, Coughlan Suzie, Clooney Lisa, LeBlanc David, Griffin Joanna, Eogan Maeve, Drew Richard J
a Royal College of Surgeons in Ireland , Dublin , Ireland.
b Department of Infection Prevention and Control , Rotunda Hospital , Dublin , Ireland.
J Matern Fetal Neonatal Med. 2018 Apr;31(8):1016-1020. doi: 10.1080/14767058.2017.1306048. Epub 2017 Apr 2.
The aim of this project was to assess the implementation of a quality improvement project regarding the introduction of on-site influenza PCR testing in a stand-alone obstetric hospital.
As part of a quality improvement project on the management of influenza in obstetric patients, the Xpert Flu assay (Cepheid Inc., Sunnyvale, CA) was introduced on-site and it replaced the previous method of PCR testing which was off-site. The main outcome measures were duration of antimicrobials, rate of admission and administration of oseltamavir in the emergency department.
Twenty-eight patients were included in the pre-intervention period and 45 patients were included in the post-intervention period. Following the introduction of the test, there was a statistically significant reduction seen in commencement of antimicrobials (76% pre- and 33% post-intervention), and also rate of admission (88% pre- and 45% post-intervention) while there was a statistically significant improvement in the commencement of oseltamavir in the emergency department (72% pre-and 95% post-intervention) (p < .01 for all outcomes).
Introduction of on-site rapid influenza PCR testing can lead to a significant improvement in patient management and should be considered for introduction to other sites.
本项目旨在评估在一家独立产科医院引入现场流感PCR检测的质量改进项目的实施情况。
作为产科患者流感管理质量改进项目的一部分，现场引入了Xpert Flu检测法（Cepheid公司，加利福尼亚州桑尼维尔），取代了之前的异地PCR检测方法。主要观察指标为抗菌药物使用时长、急诊科入院率和奥司他韦给药率。
干预前期纳入28例患者，干预后期纳入45例患者。引入该检测后，抗菌药物使用起始情况（干预前76%，干预后33%）和入院率（干预前88%，干预后45%）出现了具有统计学意义的下降，而急诊科奥司他韦使用起始情况出现了具有统计学意义的改善（干预前72%，干预后95%）（所有结果p<0.01）。
引入现场快速流感PCR检测可显著改善患者管理，应考虑在其他场所引入。
