Shubinets Valeriy, Fox Justin P, Tecce Michael G, Mirzabeigi Michael N, Lanni Michael A, Kelz Rachel R, Dumon Kristoffel R, Kovach Stephen J, Fischer John P
Division of Plastic Surgery, Department of Surgery, University of Pennsylvania Health System, Philadelphia, PA, USA.
Division of Endocrine and Oncologic Surgery, Department of Surgery, University of Pennsylvania Health System, Philadelphia, PA, USA.
J Plast Reconstr Aesthet Surg. 2017 Jun;70(6):759-767. doi: 10.1016/j.bjps.2017.01.001. Epub 2017 Jan 24.
Panniculectomy (PAN) is often performed concurrently with ventral hernia repair (VHR) in the obese patient. However, the effectiveness and safety profile of this common practice are not fully established in part because of paucity of comparative effectiveness studies. In this study, a comparative analysis of early complications, long-term hernia recurrence, and healthcare expenditures between VHR-PAN and VHR-only patients is presented.
From the Healthcare Cost and Utilization Project database, obese patients who underwent VHR with and without concurrent PAN were identified. Multivariate cox proportional-hazards regression modeling was performed to compare outcomes between the two groups.
The final cohort included 1013 VHR-PAN and 18,328 VHR-only patients. The VHR-PAN patients experienced a longer adjusted length of hospital stay (6.8 days vs. 5.2 days; p < 0.001), a higher rate of in-hospital adverse events (29.3% vs. 20.7%; AOR = 2.34 [2.01-2.74]), and a higher rate of 30-day readmissions (13.6% vs. 8.1%; AOR = 2.04 [1.69-2.48]). However, the 2-year rate of hernia recurrence was lower in the VHR-PAN group (7.9% vs. 11.3%; AOR = 0.65 [0.51-0.82]). Both groups generated considerable hospital charges ($104,805 VHR-PAN vs. $72,206 VHR-only, p < 0.001).
Performing a concurrent PAN in the obese hernia patient is associated with a higher rate of early complications and greater healthcare expenditures, but overall a substantially lower incidence of 2-year hernia recurrence. The literature review presented here also highlights a substantial need for further comparative effectiveness studies to create the needed framework for evidence-based guidelines.
在肥胖患者中,腹壁成形术(PAN)通常与腹疝修补术(VHR)同时进行。然而,由于比较有效性研究较少,这种常见做法的有效性和安全性尚未完全确立。在本研究中,对VHR-PAN组和单纯VHR组患者的早期并发症、长期疝复发及医疗费用进行了比较分析。
从医疗成本和利用项目数据库中,识别出接受VHR且有或无同时进行PAN的肥胖患者。采用多变量Cox比例风险回归模型比较两组的结局。
最终队列包括1013例VHR-PAN患者和18328例单纯VHR患者。VHR-PAN组患者的调整后住院时间更长(6.8天对5.2天;p<0.001),住院不良事件发生率更高(29.3%对20.7%;调整后比值比[AOR]=2.34[2.01-2.74]),30天再入院率更高(13.6%对8.1%;AOR=2.04[1.69-2.48])。然而,VHR-PAN组的2年疝复发率较低(7.9%对11.3%;AOR=0.65[0.51-0.82])。两组均产生了相当高的住院费用(VHR-PAN组为104,805美元,单纯VHR组为72,206美元,p<0.001)。
肥胖疝患者同时进行PAN与早期并发症发生率较高和医疗费用增加有关,但总体而言,2年疝复发率显著降低。本文的文献综述还强调,迫切需要进一步开展比较有效性研究,以建立循证指南所需的框架。