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中药保元解毒汤通过Atrogin-1和MuRF-1抑制癌症恶病质的肌肉萎缩。

Chinese Herbal Medicine Baoyuan Jiedu Decoction Inhibited Muscle Atrophy of Cancer Cachexia through Atrogin-l and MuRF-1.

作者信息

Zhang YaNan, Han XiaoChun, Ouyang Bing, Wu ZhiChun, Yu HuaYun, Wang Yuan, Liu GuoWei, Ji XuMing

机构信息

College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250355, China.

Shandong Food and Drug Administration, Jinan, Shandong 250014, China.

出版信息

Evid Based Complement Alternat Med. 2017;2017:6268378. doi: 10.1155/2017/6268378. Epub 2017 Feb 14.

DOI:10.1155/2017/6268378
PMID:28286533
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5329682/
Abstract

The aim of this study is to investigate the mechanisms of Chinese herbal medicine called "Baoyuan Jiedu" (BYJD for short) decoction, improving life quality and preventing muscle atrophy of cancer cachexia model mice. We showed that the effect of BYJD decoction increased body weights of mice and reduced tumor volume and tumor mass. Furthermore, BYJD decoction increased the gastrocnemii mass and the transverse diameter of muscle fiber morphology. Moreover, BYJD reduced the expression of Atrogin-1 and MuRF-1 protein. Collectively, our results show that BYJD decoction improves the life quality of cancer cachexia mice and prevents muscle atrophy by downregulating expression of Atrogin-1 and MuRF-1.

摘要

本研究旨在探讨中药“保元解毒”（简称BYJD）汤改善癌症恶病质模型小鼠生活质量及预防肌肉萎缩的机制。我们发现，BYJD汤可增加小鼠体重，减小肿瘤体积和肿瘤质量。此外，BYJD汤增加了腓肠肌质量和肌纤维形态的横径。而且，BYJD降低了Atrogin-1和MuRF-1蛋白的表达。总体而言，我们的结果表明，BYJD汤通过下调Atrogin-1和MuRF-1的表达来改善癌症恶病质小鼠的生活质量并预防肌肉萎缩。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2096/5329682/71ec653ea972/ECAM2017-6268378.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2096/5329682/6a55a69c3b42/ECAM2017-6268378.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2096/5329682/af4ade5d87ec/ECAM2017-6268378.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2096/5329682/60cab93fe6d5/ECAM2017-6268378.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2096/5329682/7b039f0a3161/ECAM2017-6268378.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2096/5329682/d7a69b8956da/ECAM2017-6268378.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2096/5329682/71ec653ea972/ECAM2017-6268378.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2096/5329682/6a55a69c3b42/ECAM2017-6268378.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2096/5329682/af4ade5d87ec/ECAM2017-6268378.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2096/5329682/60cab93fe6d5/ECAM2017-6268378.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2096/5329682/7b039f0a3161/ECAM2017-6268378.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2096/5329682/d7a69b8956da/ECAM2017-6268378.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2096/5329682/71ec653ea972/ECAM2017-6268378.006.jpg

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