心血管生物标志物及其在老年人中的应用。
Cardiovascular biomarkers and their utility in the older adult.
作者信息
Bell Susan P, Giuseffi Jennifer L, Forman Daniel E
机构信息
Vanderbilt University Medical Center, Division of Cardiovascular Medicine, 383 PRB, 2220 Pierce Avenue, Nashville, TN 37232-6300.
-Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, -New England GRECC (Geriatric Research, Education, and Clinical Center), Boston VA Healthcare System, Boston, MA.
出版信息
Curr Cardiovasc Risk Rep. 2012 Oct;6(5):397-403. doi: 10.1007/s12170-012-0262-0. Epub 2012 Jul 28.
Cardiovascular disease is the leading cause of morbidity and mortality in individuals over the age of 65 yet diagnosis, risk stratification and management continue to be more challenging than in younger adults due to the vast heterogeneity seen in this population. The current literature validates the use of biomarkers in addition to traditional risk assessment tools in younger and middle aged adults. The evidence for biomarkers in this older population is sparse; this review examines the epidemiological association of current biomarkers in the field and the utility of these markers in the diagnosis, risk discrimination and management of cardiovascular disease.
心血管疾病是65岁以上人群发病和死亡的主要原因。然而，由于该人群存在巨大的异质性，其诊断、风险分层和管理比年轻成年人更具挑战性。目前的文献证实，除了传统的风险评估工具外，生物标志物在年轻和中年成年人中也有应用。在老年人群中，生物标志物的证据很少；本综述探讨了该领域当前生物标志物的流行病学关联以及这些标志物在心血管疾病诊断、风险判别和管理中的效用。
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