一种源自黄芪的四种黄酮类化合物的新型组合可缓解环磷酰胺诱导的贫血大鼠的症状。
A novel combination of four flavonoids derived from Astragali Radix relieves the symptoms of cyclophosphamide-induced anemic rats.
作者信息
Zhang Li, Gong Amy G W, Riaz Kashif, Deng Jun Y, Ho Chih M, Lin Huang Q, Dong Tina T X, Lee Yi-Kuen, Tsim Karl W K
机构信息
Division of Life Science and Center for Chinese Medicine The Hong Kong University of Science and Technology China; School of Pharmacy Shanghai University of Traditional Chinese Medicine China.
Division of Life Science and Center for Chinese Medicine The Hong Kong University of Science and Technology China.
出版信息
FEBS Open Bio. 2017 Jan 28;7(3):318-323. doi: 10.1002/2211-5463.12146. eCollection 2017 Mar.
Abstract
By using a feedback system control scheme, the best combination of formononetin, ononin, calycosin, and calycosin-7--β-d-glucoside derived from Astragali Radix was shown to activate a hypoxia response element, a regulator for erythropoietin (EPO) transcription, in kidney fibroblast. In cyclophosphamide-induced anemic rats, the treatment of combined flavonoids, or EPO, improved the levels of red blood cells, white blood cells, hemoglobin, and hematocrit. In addition, the altered levels of antioxidant capacity, super oxidase dismutase, and malondialdehyde, triggered in anemic rats, were restored to control levels by the treatment of flavonoids. Here, we proposed a possible therapy by using the common flavonoids in treating anemia.
摘要
通过使用反馈系统控制方案，结果表明，从黄芪中提取的芒柄花素、芒柄花苷、毛蕊异黄酮和毛蕊异黄酮-7-O-β-D-葡萄糖苷的最佳组合可激活缺氧反应元件，这是一种促红细胞生成素（EPO）转录的调节因子，在肾成纤维细胞中发挥作用。在环磷酰胺诱导的贫血大鼠中，联合使用黄酮类化合物或EPO进行治疗，可提高红细胞、白细胞、血红蛋白和血细胞比容水平。此外，贫血大鼠体内引发的抗氧化能力、超氧化物歧化酶和丙二醛水平的改变，通过黄酮类化合物治疗可恢复至对照水平。在此，我们提出了一种使用常见黄酮类化合物治疗贫血的可能疗法。
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