Department of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 211198, Jiangsu Province, China.
Center for Translational Medicine and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing, 210093, People's Republic of China.
Int Urol Nephrol. 2021 Aug;53(8):1515-1528. doi: 10.1007/s11255-021-02868-w. Epub 2021 Apr 27.
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is the most frequent form of prostatitis, and has a serious impact on patients' quality of life, and causes severe symptoms. The pain in the pelvic, perineal and penile areas, lower abdominal pain, and pain during urination or ejaculation are the main complaints of CP/CPPS. The underlying complex and unknown pathophysiology of this syndrome have made the management of CP/CPPS and the availability of monotherapy challenging. To identify an effective monotherapy, a plethora of clinical trials failed due to its puzzling etiology. Antibiotics, anti-inflammatory, and a-blockers have been commonly used for the treatment of CP/CPPS, but the desired and complete effects have not been gotten yet. The patients and clinicians are attracted to alternative therapies because of their multi-targeted effects. Attention toward natural compounds effectiveness and safety, supporting the development of a new nutraceutical science. In the alternative remedies for the treatment of prostatic diseases, medicinal herbs, in the form of herb parts or extracts, are getting attention due to their positive effects on prostatic diseases. At present, there is no available detailed literature review about the efficacy of medicinal herbs in the treatment of CP/CPPS. This review aimed to explore the useful medicinal herbs in the treatment of CP/CPPS from different perspectives and their possible mechanism of action in managing CP/CPPS.
慢性前列腺炎/慢性盆腔疼痛综合征（CP/CPPS）是前列腺炎中最常见的一种，对患者的生活质量有严重影响，并导致严重的症状。骨盆、会阴和阴茎区域疼痛、下腹痛、排尿或射精时疼痛是 CP/CPPS 的主要症状。该综合征的潜在复杂和未知的病理生理学使得 CP/CPPS 的管理和单一疗法的可用性具有挑战性。为了确定有效的单一疗法，由于其令人费解的病因，大量临床试验都失败了。抗生素、抗炎药和α-阻滞剂通常用于治疗 CP/CPPS，但尚未获得预期的完全疗效。由于其多靶点作用，患者和临床医生都倾向于选择替代疗法。对天然化合物有效性和安全性的关注，支持了新的营养科学的发展。在治疗前列腺疾病的替代疗法中，草药以草药部分或提取物的形式受到关注，因为它们对前列腺疾病有积极的影响。目前，关于草药治疗 CP/CPPS 的疗效，还没有详细的文献综述。本综述旨在从不同角度探讨治疗 CP/CPPS 的有用草药及其在治疗 CP/CPPS 方面的可能作用机制。
