Holmberg S D, Stewart J A, Gerber A R, Byers R H, Lee F K, O'Malley P M, Nahmias A J
AIDS Program, Centers for Disease Control, Atlanta, GA 30333.
JAMA. 1988 Feb 19;259(7):1048-50.
Antibodies to cytomegalovirus (CMV), Epstein-Barr virus (EBV), and herpes simplex viruses types 1 and 2 (HSV-1, HSV-2) in three sequential serum samples from 62 men who did and 61 men who did not develop human immunodeficiency virus (HIV) infection at the time of the final (third) serum specimen were studied. Antibody titers to CMV, EBV, and HSV-1 did not significantly rise in or differ between men who did or did not get HIV infection. However, we found that 32 (68%) of 47 HIV seroconverters had antibodies to HSV-2 at the time the third specimen was drawn, whereas only 26 (46%) of 57 men who remained HIV seronegative had HSV-2 antibody positivity. Seroconversion to HSV-2 between any two serum specimens was found in 11 (42%) of the 26 HIV seroconverters but in only five (14%) of 35 men who remained HIV seronegative. The association between HSV-2 seropositivity (or seroconversion) and subsequent or concurrent HIV seroconversion remained when we controlled for factors known to influence HIV infection, including age, number of sexual partners, and percentage of sexual acts involving receptive anal intercourse. These serologic studies do not support the role of CMV, EBV, or HSV-1 in HIV infection but do suggest that HSV-2 infection is a risk factor for subsequent or concurrent HIV infection.
对62名最终（第三次）血清样本采集时感染了人类免疫缺陷病毒（HIV）的男性和61名未感染HIV的男性的三份连续血清样本中的巨细胞病毒（CMV）、爱泼斯坦-巴尔病毒（EBV）以及1型和2型单纯疱疹病毒（HSV-1、HSV-2）抗体进行了研究。感染或未感染HIV的男性中，CMV、EBV和HSV-1的抗体滴度均未显著升高，也无差异。然而，我们发现，47名HIV血清转化者中有32名（68%）在采集第三次样本时具有HSV-2抗体，而57名HIV血清学仍为阴性的男性中只有26名（46%）HSV-2抗体呈阳性。在26名HIV血清转化者中有11名（42%）在任意两份血清样本之间出现了HSV-2血清转化，而在35名HIV血清学仍为阴性的男性中只有5名（14%）出现了这种情况。在我们对已知影响HIV感染的因素（包括年龄、性伴侣数量以及涉及接受肛交性行为的比例）进行控制后，HSV-2血清阳性（或血清转化）与随后或同时发生的HIV血清转化之间的关联依然存在。这些血清学研究不支持CMV、EBV或HSV-1在HIV感染中所起的作用，但确实表明HSV-2感染是随后或同时发生HIV感染的一个危险因素。
