Yau Adora M W, McLaughlin John, Maughan Ronald J, Gilmore William, Evans Gethin H
School of Healthcare Science, Manchester Metropolitan University, Manchester, Greater Manchester M1 5GD, UK.
Institute of Inflammation and Repair, Faculty of Medical and Human Sciences, University of Manchester, Manchester, Greater Manchester M13 9PT, UK.
Nutrients. 2017 Mar 10;9(3):258. doi: 10.3390/nu9030258.
This study aimed to examine gastric emptying rate and gastrointestinal hormone responses to fructose and glucose ingestion following 3 days of dietary fructose supplementation. Using the C-breath test method, gastric emptying rates of equicaloric fructose and glucose solutions were measured in 10 healthy men with prior fructose supplementation (fructose supplement, FS; glucose supplement, GS) and without prior fructose supplementation (fructose control, FC; glucose control, GC). In addition, circulating concentrations of acylated ghrelin (GHR), glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and insulin were determined, as well as leptin, lactate, and triglycerides. Increased dietary fructose ingestion resulted in accelerated gastric emptying rate of a fructose solution but not a glucose solution. No differences in GIP, GLP-1, or insulin incremental area under curve (iAUC) were found between control and supplement trials for either fructose or glucose ingestion. However, a trend for lower ghrelin iAUC was observed for FS compared to FC. In addition, a trend of lower GHR concentration was observed at 45 min for FS compared to FC and GHR concentration for GS was greater than GC at 10 min. The accelerated gastric emptying rate of fructose following short-term supplementation with fructose may be partially explained by subtle changes in delayed postprandial ghrelin suppression.
本研究旨在探讨在补充果糖饮食3天后，摄入果糖和葡萄糖时的胃排空率及胃肠激素反应。采用碳呼气试验法，在10名健康男性中测量等热量果糖溶液和葡萄糖溶液的胃排空率，这些男性分为两组，一组先前补充过果糖（果糖补充组，FS；葡萄糖补充组，GS），另一组未补充过果糖（果糖对照组，FC；葡萄糖对照组，GC）。此外，还测定了酰化胃饥饿素（GHR）、胰高血糖素样肽-1（GLP-1）、葡萄糖依赖性促胰岛素多肽（GIP）和胰岛素的循环浓度，以及瘦素、乳酸和甘油三酯。增加果糖摄入量会导致果糖溶液的胃排空率加快，但葡萄糖溶液的胃排空率不受影响。在果糖或葡萄糖摄入的对照组和补充组试验之间，未发现GIP、GLP-1或胰岛素曲线下增量面积（iAUC）有差异。然而，与FC相比，FS的胃饥饿素iAUC有降低趋势。此外，与FC相比，FS在45分钟时的GHR浓度有降低趋势，且GS在10分钟时的GHR浓度高于GC。短期补充果糖后果糖胃排空率加快，可能部分是由于餐后胃饥饿素抑制延迟的细微变化所致。
