Ramírez Gómez Carolina Candelaria, Serrano Dueñas Marcos, Bernal Oscar, Araoz Natalia, Sáenz Farret Michel, Aldinio Victoria, Montilla Verónica, Micheli Federico
*Parkinson's Disease and Movement Disorder Unit, Hospital de Clínicas "José de San Martín," School of Medicine, University of Buenos Aires, Buenos Aires, Argentina; †School of Medicine, Pontifical Catholic University of Ecuador, and Neurological Unit, "Carlos Andrade Marín" Hospital, Quito, Ecuador; and ‡Nueva Granada Military University, Military Hospital, Santa Fe de Bogotá Foundation, Bogotá, Colombia.
Clin Neuropharmacol. 2017 Mar/Apr;40(2):51-55. doi: 10.1097/WNF.0000000000000202.
Impulse control disorder (ICD) is a common adverse effect in patients with Parkinson disease who receive dopamine agonists; however, other factors are involved in its manifestations. To study the frequency and factors involved in the development of this adverse effect in a Latin American population, we conducted a cross-sectional multicenter study.
Two hundred fifty-five patients in 3 Latin American centers were evaluated by examination and application of scales (Unified Parkinson's Disease Rating Scale, Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale, Hoehn and Yahr, Clinical Impression of Severity Index for Parkinson's Disease).
Of the patients, 27.4% had ICD, most of whom were on dopamine agonists. Other associated risk factors included a younger age at onset of Parkinson disease, moderate symptoms, a shorter evolution of the clinical manifestations, rapid eye movement (REM) sleep disorder behavior, and the consumption of tea, mate, and alcohol.
The frequency of ICD is higher in Latin America than in Anglo-Saxon populations. Consuming tea and mate, in addition to the use of dopamine agonists, is a factor that may demonstrate a genetic link that predisposes patients to the establishment of an ICD.
冲动控制障碍（ICD）是接受多巴胺激动剂治疗的帕金森病患者常见的不良反应；然而，其表现还涉及其他因素。为研究拉丁美洲人群中这种不良反应发生的频率及相关因素，我们开展了一项横断面多中心研究。
对拉丁美洲3个中心的255例患者进行检查并应用量表评估（统一帕金森病评定量表、帕金森病冲动控制障碍问卷评定量表、霍恩和雅尔分级、帕金森病严重程度临床印象指数）。
患者中27.4%患有ICD，其中大多数正在使用多巴胺激动剂。其他相关危险因素包括帕金森病发病年龄较轻、症状中等、临床表现病程较短、快速眼动（REM）睡眠行为障碍以及茶、马黛茶和酒精的摄入。
拉丁美洲ICD的发生率高于盎格鲁 - 撒克逊人群。除使用多巴胺激动剂外，饮用茶和马黛茶可能是一个表明存在遗传联系的因素，使患者易患ICD。
