Spiller Cassy M, Bowles Josephine
School of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia.
School of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
Int J Biochem Cell Biol. 2017 May;86:22-25. doi: 10.1016/j.biocel.2017.03.004. Epub 2017 Mar 10.
Germ cell neoplasia in situ is the non-invasive precursor cell of origin for type II testicular germ cell tumors. It has long been postulated that germ cell neoplasia in situ is derived from defective germ cell development during embryonic life, and although it is impossible to trace in vivo the progression from fetal germ cell to germ cell neoplasia in situ to tumor, there is a large volume of evidence supporting this theory. Current studies focus on understanding how germ cell neoplasia in situ forms, how these cells are activated at puberty and how they transform to invasive tumors of various subtypes. Such information is informing novel diagnostic and therapeutic options.
原位生殖细胞肿瘤是II型睾丸生殖细胞肿瘤的非侵袭性起源前体细胞。长期以来，人们一直推测原位生殖细胞肿瘤源自胚胎期生殖细胞发育缺陷，尽管无法在体内追踪从胎儿生殖细胞到原位生殖细胞肿瘤再到肿瘤的进展过程，但有大量证据支持这一理论。目前的研究集中在了解原位生殖细胞肿瘤是如何形成的，这些细胞在青春期是如何被激活的，以及它们是如何转化为各种亚型的侵袭性肿瘤的。这些信息为新的诊断和治疗选择提供了依据。
