Kotenko Sergei V, Durbin Joan E
From the Departments of Microbiology, Biochemistry and Molecular Genetics and
Center for Immunity and Inflammation, and.
J Biol Chem. 2017 May 5;292(18):7295-7303. doi: 10.1074/jbc.R117.777102. Epub 2017 Mar 13.
Type I interferons (IFN-α/β) and the more recently identified type III IFNs (IFN-λ) function as the first line of defense against virus infection and regulate the development of both innate and adaptive immune responses. Type III IFNs were originally identified as a novel ligand-receptor system acting in parallel with type I IFNs, but subsequent studies have provided increasing evidence for distinct roles for each IFN family. In addition to their compartmentalized antiviral actions, these two systems appear to have multiple levels of cross-regulation and act coordinately to achieve effective antimicrobial protection with minimal collateral damage to the host.
I型干扰素（IFN-α/β）以及最近发现的III型干扰素（IFN-λ）作为抵御病毒感染的第一道防线，调节先天性和适应性免疫反应的发展。III型干扰素最初被鉴定为与I型干扰素并行起作用的新型配体-受体系统，但随后的研究越来越多地证明每个干扰素家族具有不同的作用。除了其分区化的抗病毒作用外，这两个系统似乎具有多个交叉调节水平，并协同作用以实现有效的抗菌保护，同时对宿主造成最小的附带损害。
