Wakabayashi Yuichi, Ishii Kazunari, Hosokawa Chisa, Hyodo Tomoko, Kaida Hayato, Yamada Minoru, Yagyu Yukinobu, Tsurusaki Masakatsu, Kozuka Takenori, Sugimura Kazuro, Murakami Takamichi
Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
Department of Radiology, Kindai University Faculty of Medicine, Osakasayama, Osaka, Japan.
Kobe J Med Sci. 2017 Mar 13;62(5):E136-E141.
Using 11C-Pittsburgh compound B (PiB)-PET and MRI volume data, we investigated whether white matter (WM) PiB uptake in Alzheimer's disease (AD) brain is larger than that of cortical PiB uptake-negative (PiB-negative) brain. Forty-five subjects who underwent both PiB-PET and MRI were included in the study (32 AD patients with cortical PiB-positive and 13 cortical amyloid -negative patients). Individual areas of gray matter (GM) and WM were segmented, then regional GM and WM standard uptake value ratio (SUVR) normalized to cerebellar GM with partial volume effects correction was calculated. Three regional SUVRs except WM in the centrum semiovale in the AD group were significantly larger than those in the PiB-negative groups. Frontal WM SUVR in the AD group vs frontal WM SUVR in the PiB-negative group was 2.57 ± 0.55 vs 1.64 ± 0.22; parietal, 2.50 ± 0.52 vs 1.74 ± 0.22; posterior cingulate, 2.84 ± 0.59 vs 1.73 ± 0.22; and WM in the centrum semiovale, 2.21 ± 0.53 vs 2.42 ± 0.36, respectively. We found that PiB uptake in AD brain is significantly larger than that in PiB-negative brain in the frontal, parietal and posterior cingulate subcortical WM, except in the centrum semiovale.
利用11C-匹兹堡化合物B（PiB）-PET和MRI体积数据，我们研究了阿尔茨海默病（AD）脑白质（WM）中PiB摄取是否大于皮质PiB摄取阴性（PiB阴性）脑。45名同时接受PiB-PET和MRI检查的受试者纳入研究（32例皮质PiB阳性的AD患者和13例皮质淀粉样蛋白阴性患者）。对灰质（GM）和WM的各个区域进行分割，然后计算校正部分容积效应后以小脑GM为标准的区域GM和WM标准摄取值比率（SUVR）。AD组中除半卵圆中心WM外的三个区域SUVR显著高于PiB阴性组。AD组额叶WM SUVR与PiB阴性组额叶WM SUVR分别为2.57±0.55和1.64±0.22；顶叶分别为2.50±0.52和1.74±0.22；后扣带回分别为2.84±0.59和1.73±0.22；半卵圆中心WM分别为2.21±0.53和2.42±0.36。我们发现，除半卵圆中心外，AD脑额叶、顶叶和后扣带回皮质下WM中的PiB摄取显著大于PiB阴性脑。
