使用 [11C]AZD2184 进行早期阿尔茨海默病的皮质下和皮质淀粉样蛋白-β的高对比度 PET 成像。
High Contrast PET Imaging of Subcortical and Allocortical Amyloid-β in Early Alzheimer's Disease Using [11C]AZD2184.
机构信息
Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet and Stockholm Health Care Services, Stockholm, Sweden.
PET Science Centre, Personalized Medicine and Biosamples, R&D, AstraZeneca, Stockholm, Sweden.
出版信息
J Alzheimers Dis. 2024;98(4):1391-1401. doi: 10.3233/JAD-231013.
BACKGROUND
Deposits of amyloid-β (Aβ) appear early in Alzheimer's disease (AD).
OBJECTIVE
The aim of the present study was to compare the presence of cortical and subcortical Aβ in early AD using positron emission tomography (PET).
METHODS
Eight cognitively unimpaired (CU) subjects, 8 with mild cognitive impairment (MCI) and 8 with mild AD were examined with PET and [11C]AZD2184. A data driven cut-point for Aβ positivity was defined by Gaussian mixture model of isocortex binding potential (BPND) values.
RESULTS
Sixteen subjects (3 CU, 5 MCI and 8 AD) were Aβ-positive. BPND was lower in subcortical and allocortical regions compared to isocortex. Fifteen of the 16 Aβ-positive subjects displayed Aβ binding in striatum, 14 in thalamus and 10 in allocortical regions.
CONCLUSIONS
Aβ deposits appear to be widespread in early AD. It cannot be excluded that deposits appear simultaneously throughout the whole brain which has implications for improved diagnostics and disease monitoring.
背景
淀粉样蛋白-β（Aβ）沉积在阿尔茨海默病（AD）的早期就出现了。
目的
本研究旨在使用正电子发射断层扫描（PET）比较早期 AD 患者皮质和皮质下 Aβ 的存在情况。
方法
对 8 名认知正常（CU）受试者、8 名轻度认知障碍（MCI）和 8 名轻度 AD 患者进行了 PET 和[11C]AZD2184 检查。通过对同型皮质结合潜能（BPND）值进行高斯混合模型分析，定义了 Aβ阳性的数据分析驱动截断值。
结果
16 名受试者（3 名 CU、5 名 MCI 和 8 名 AD）为 Aβ 阳性。与同型皮质相比，皮质下和外皮质区域的 BPND 较低。16 名 Aβ 阳性受试者中有 15 名在纹状体、14 名在丘脑和 10 名在外皮质区域显示 Aβ 结合。
结论
在早期 AD 中，Aβ 沉积似乎广泛存在。不能排除 Aβ 沉积在整个大脑中同时出现，这对改善诊断和疾病监测具有重要意义。
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