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从夸休可尔症患者肠道中分离出的新属、新种的基因组序列及描述

Genome sequence and description of gen. nov., sp. nov., isolated from the gut of patient with kwashiorkor.

作者信息

Guilhot E, Alou M T, Lagier J-C, Labas N, Couderc C, Delerce J, Diallo A, Sokhna C, Fournier P-E, Raoult D, Khelaifia S

机构信息

Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes IRD 198, CNRS 7278, UM63, INSERM 1095, Aix-Marseille Université, Institut Hospitalo-Universitaire Méditerranée-Infection, Faculté de médecine, Marseille, France.

Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes IRD 198, CNRS 7278, Aix-Marseille Université, Marseille, France; Campus Commun UCAD-IRD of Hann, Dakar, Senegal.

出版信息

New Microbes New Infect. 2017 Feb 2;17:54-64. doi: 10.1016/j.nmni.2017.01.009. eCollection 2017 May.

DOI:10.1016/j.nmni.2017.01.009
PMID:28289546
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5338722/
Abstract

Using the culturomics strategy, a wide range of anaerobic bacteria was discovered including strain mt9 (= CSUR P1511 = DSM 102954), isolated from the gut microbiota of a 1-year-old Senegalese patient with kwashiorkor. This Gram-negative strain is a strictly anaerobic, spore-forming rod motile by a polar flagellum. The 3 511 289 bp long genome of this strain contains 3046 protein-coding and 49 RNA genes, including 45 tRNA and four rRNA genes, and exhibits a G+C content of 52.94%. Here we describe the features of this organism, together with the complete genome sequence and annotation.

摘要

采用文化组学策略,发现了多种厌氧细菌,包括从一名患有夸休可尔症的1岁塞内加尔患者肠道微生物群中分离出的菌株mt9(=CSUR P1511 = DSM 102954)。这种革兰氏阴性菌株是一种严格厌氧、形成芽孢的杆菌,通过极鞭毛运动。该菌株3511289 bp长的基因组包含3046个蛋白质编码基因和49个RNA基因,其中包括45个tRNA基因和4个rRNA基因,G+C含量为52.94%。在此,我们描述了该生物体的特征以及完整的基因组序列和注释。

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