从夸休可尔症患者肠道中分离出的新属、新种的基因组序列及描述
Genome sequence and description of gen. nov., sp. nov., isolated from the gut of patient with kwashiorkor.
作者信息
Guilhot E, Alou M T, Lagier J-C, Labas N, Couderc C, Delerce J, Diallo A, Sokhna C, Fournier P-E, Raoult D, Khelaifia S
机构信息
Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes IRD 198, CNRS 7278, UM63, INSERM 1095, Aix-Marseille Université, Institut Hospitalo-Universitaire Méditerranée-Infection, Faculté de médecine, Marseille, France.
Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes IRD 198, CNRS 7278, Aix-Marseille Université, Marseille, France; Campus Commun UCAD-IRD of Hann, Dakar, Senegal.
出版信息
New Microbes New Infect. 2017 Feb 2;17:54-64. doi: 10.1016/j.nmni.2017.01.009. eCollection 2017 May.
Using the culturomics strategy, a wide range of anaerobic bacteria was discovered including strain mt9 (= CSUR P1511 = DSM 102954), isolated from the gut microbiota of a 1-year-old Senegalese patient with kwashiorkor. This Gram-negative strain is a strictly anaerobic, spore-forming rod motile by a polar flagellum. The 3 511 289 bp long genome of this strain contains 3046 protein-coding and 49 RNA genes, including 45 tRNA and four rRNA genes, and exhibits a G+C content of 52.94%. Here we describe the features of this organism, together with the complete genome sequence and annotation.
采用文化组学策略，发现了多种厌氧细菌，包括从一名患有夸休可尔症的1岁塞内加尔患者肠道微生物群中分离出的菌株mt9（=CSUR P1511 = DSM 102954）。这种革兰氏阴性菌株是一种严格厌氧、形成芽孢的杆菌，通过极鞭毛运动。该菌株3511289 bp长的基因组包含3046个蛋白质编码基因和49个RNA基因，其中包括45个tRNA基因和4个rRNA基因，G+C含量为52.94%。在此，我们描述了该生物体的特征以及完整的基因组序列和注释。
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