Rocha Ana L, Vieira Erica L, Ferreira Márcia C, Maia Laura M, Teixeira Antonio L, Reis Fernando M
Department of Obstetrics & Gynecology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Department of Internal Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Biomark Med. 2017 Apr;11(4):313-317. doi: 10.2217/bmm-2016-0327. Epub 2017 Mar 14.
To test whether plasma BDNF levels are useful to predict the presence of endometriosis in women with pelvic pain.
PATIENTS & METHODS: Prospective cross-sectional study including 67 consecutive women aged 24-49 years, scheduled for laparoscopy due to chronic pelvic pain. Preoperative plasma samples were assayed for BDNF using a commercial enzyme immunoassay.
Women with ovarian endometrioma had higher preoperative plasma BDNF (1063 ± 157 pg/ml) compared with women with other benign ovarian tumors (537 ± 131 pg/ml, F = 2.53; p = 0.02). However, plasma BDNF levels were not helpful to indicate the presence of peritoneal or deep infiltrating endometriosis. Plasma BDNF levels were positively correlated with the severity of pelvic pain (r = 0.489; p < 0.0001).
Plasma BDNF might be a biomarker of ovarian endometrioma but not a useful diagnostic marker to detect other forms of endometriosis in women with painful symptoms.
检测血浆脑源性神经营养因子（BDNF）水平是否有助于预测盆腔疼痛女性子宫内膜异位症的存在。
前瞻性横断面研究，纳入67例年龄在24至49岁之间因慢性盆腔疼痛计划行腹腔镜检查的连续女性。术前采集血浆样本，使用商业酶免疫测定法检测BDNF。
卵巢子宫内膜异位囊肿女性术前血浆BDNF水平（1063±157 pg/ml）高于其他良性卵巢肿瘤女性（537±131 pg/ml，F=2.53；p=0.02）。然而，血浆BDNF水平无助于提示腹膜或深部浸润性子宫内膜异位症的存在。血浆BDNF水平与盆腔疼痛严重程度呈正相关（r=0.489；p<0.0001）。
血浆BDNF可能是卵巢子宫内膜异位囊肿的生物标志物，但不是检测有疼痛症状女性其他形式子宫内膜异位症的有用诊断标志物。
