Lin Liqiang, Zeng Xiaowei
a Department of Mechanical Engineering , University of Texas at San Antonio , San Antonio , TX , USA.
Comput Methods Biomech Biomed Engin. 2017 Jun;20(8):832-841. doi: 10.1080/10255842.2017.1303051. Epub 2017 Mar 14.
Tethering and rolling of circulating leukocytes on the surface of endothelium are critical steps during an inflammatory response. A soft solid cell model was proposed to study monocytes tethering and rolling behaviors on substrate surface in shear flow. The interactions between monocytes and micro-channel surface were modeled by a coarse-grained molecular adhesive potential. The computational model was implemented in a Lagrange-type meshfree Galerkin formulation to investigate the monocyte tethering and rolling process with different flow rates. From the simulation results, it was found that the flow rate has profound effects on the rolling velocity, contact area and effective stress of monocytes. As the flow rate increased, the rolling velocity would increase linearly, whereas the contact area and average effective stress in monocyte showed nonlinear increase.
循环白细胞在内皮表面的 tethering 和滚动是炎症反应过程中的关键步骤。提出了一种软固体细胞模型来研究单核细胞在剪切流中在底物表面的 tethering 和滚动行为。单核细胞与微通道表面之间的相互作用通过粗粒度分子粘附势进行建模。该计算模型采用拉格朗日型无网格伽辽金公式实现，以研究不同流速下单核细胞的 tethering 和滚动过程。从模拟结果发现，流速对单核细胞的滚动速度、接触面积和有效应力有深远影响。随着流速增加，滚动速度将线性增加，而单核细胞中的接触面积和平均有效应力呈非线性增加。
