Karpov On Behalf Of Participants Of The Prometheus Study Yu A
Russian Cardiology Research and Production Complex, Moscow, Russia.
Kardiologiia. 2016 Jul;56(7):63-71.
The main purpose of the study was to estimate prevalence of subjects with hypertriglyceridemia (HTG) in Russia. Secondary objectives were to explore HTG prevalence by levels, age and sex, and to assess correlation between glycated hemoglobin (HbA1C) and triglyceride (TG) level. Additionally, we analyzed geographical differences in HTG prevalence in regions of Russia.
This was a cross-sectional, retrospective, observational study using database of results of lipid profile determination in 357,072 subjects from 254 Russian cities during the 3-year period from 2011 to 2013.
Altogether, 29.2% (95% confidence interval [CI] 29.1-29.4%) of Russian individuals had HTG (serum TG more or equal 1.7 mmol/L). The percentage of patients with very high (TG more or equal 5.6 mmol/L) and severe HTG (TG more or equal 10.0mmol/L) was low (0.01% and 0.011%, respectively). At the same time, the portion of subjects with mixed hyperlipidemia (total cholesterol [TC] more or equal 5.2mmol/L, low-density lipoprotein cholesterol [LDL-C] more or equal 3.4 mmol/L, TG more or equal 1.7 mmol/L) was 19% of the study population. Men had 1.25 (95% CI, 1.24-1.26) times higher risk of HTG than women. Prevalence of HTG increased with age: in women TG level was maximal in the age group 60-69 years (34%), whereas in men TG level was maximal in the age group 40-49 years (43%). Prevalence of HTG increased from 2011 to 2013 from 28 to 30% (p<0.0001). Risk of HTG was 1.69 times greater when high HbA1C more or equal 6.5% was present, and vice versa, risk of HbA1C more or equal 6.5% was 2.04 times higher in individuals with HTG. Distribution of HTG and dyslipidemia by regions of Russia had large variability being higher in the south and lower in the northern regions of European part of Russia.
Almost a third of Russian population has HTG. Men have higher risk of HTG than women. Prevalence of HTG increases with age and reaches its peak in age groups 60-69 years in (women) and 40-49 years (men). There is a linear association between high HbA- and high level of TG. Prevalence of HTG and dyslipidemia is heterogeneous in Russian regions.
本研究的主要目的是估计俄罗斯高甘油三酯血症（HTG）患者的患病率。次要目标是按水平、年龄和性别探讨HTG患病率，并评估糖化血红蛋白（HbA1C）与甘油三酯（TG）水平之间的相关性。此外，我们分析了俄罗斯各地区HTG患病率的地理差异。
这是一项横断面、回顾性观察性研究，使用了2011年至2013年3年间来自俄罗斯254个城市的357,072名受试者的血脂谱测定结果数据库。
总体而言，29.2%（95%置信区间[CI]29.1 - 29.4%）的俄罗斯人患有HTG（血清TG≥1.7 mmol/L）。极高（TG≥5.6 mmol/L）和重度HTG（TG≥10.0 mmol/L）患者的比例较低（分别为0.01%和0.011%）。同时，混合性高脂血症（总胆固醇[TC]≥5.2 mmol/L、低密度脂蛋白胆固醇[LDL - C]≥3.4 mmol/L、TG≥1.7 mmol/L）患者占研究人群的19%。男性患HTG的风险比女性高1.25倍（95% CI，1.24 - 1.26）。HTG患病率随年龄增加：女性TG水平在60 - 69岁年龄组最高（34%），而男性TG水平在40 - 49岁年龄组最高（43%）。HTG患病率从2011年到2013年从28%升至30%（p<0.0001）。当存在高HbA1C≥6.5%时，HTG风险高1.69倍，反之，HTG患者中HbA1C≥6.5%的风险高2.04倍。俄罗斯各地区HTG和血脂异常的分布差异很大，俄罗斯欧洲部分南部地区较高，北部地区较低。
近三分之一的俄罗斯人口患有HTG。男性患HTG的风险高于女性。HTG患病率随年龄增加，并在60 - 69岁年龄组（女性）和40 - 49岁年龄组（男性）达到峰值。高HbA1C与高TG水平之间存在线性关联。俄罗斯各地区HTG和血脂异常的患病率存在异质性。
