Institute of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, People's Republic of China.
MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systematic Biology, School of Life Sciences, Tsinghua University, Beijing, People's Republic of China.
Cell Death Dis. 2022 Mar 25;13(3):267. doi: 10.1038/s41419-022-04713-z.
Nicotinamide N-methyltransferase (NNMT) is an intracellular methyltransferase, catalyzing the N-methylation of nicotinamide (NAM) to form 1-methylnicotinamide (1-MNAM), in which S-adenosyl-L-methionine (SAM) is the methyl donor. High expression of NNMT can alter cellular NAM and SAM levels, which in turn, affects nicotinamide adenine dinucleotide (NAD)-dependent redox reactions and signaling pathways, and remodels cellular epigenetic states. Studies have revealed that NNMT plays critical roles in the occurrence and development of various cancers, and analysis of NNMT expression levels in different cancers from The Cancer Genome Atlas (TCGA) dataset indicated that NNMT might be a potential biomarker and therapeutic target for tumor diagnosis and treatment. This review provides a comprehensive understanding of recent advances on NNMT functions in different tumors and deciphers the complex roles of NNMT in cancer progression.
烟酰胺 N-甲基转移酶（NNMT）是一种细胞内甲基转移酶，可催化烟酰胺（NAM）的 N-甲基化，形成 1-甲基烟酰胺（1-MNAM），其中 S-腺苷甲硫氨酸（SAM）是甲基供体。NNMT 的高表达可以改变细胞内 NAM 和 SAM 的水平，进而影响烟酰胺腺嘌呤二核苷酸（NAD）依赖的氧化还原反应和信号通路，并重塑细胞表观遗传状态。研究表明，NNMT 在各种癌症的发生和发展中起着关键作用，对癌症基因组图谱（TCGA）数据库中不同癌症的 NNMT 表达水平进行分析表明，NNMT 可能是肿瘤诊断和治疗的潜在生物标志物和治疗靶点。本综述全面了解了 NNMT 在不同肿瘤中的功能的最新进展，并解析了 NNMT 在癌症进展中的复杂作用。
