硫酸铁联合矿物三氧化物凝聚体活髓切断术与氧化锌丁香油糊剂牙髓摘除术治疗上颌乳切牙的比较：一项为期18个月的随机对照试验。

Comparison of Ferric Sulfate Combined Mineral Trioxide Aggregate Pulpotomy and Zinc Oxide Eugenol Pulpectomy of Primary Maxillary Incisors: An 18-month Randomized, Controlled Trial.

作者信息

Nguyen Trang D, Judd Peter L, Barrett Edward J, Sidhu Nicole, Casas Michael J

机构信息

Division Chief, Pediatric Dentistry, Janeway Children's Health and Rehabilitation Centre, and a clinical assistant professor, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada.

Dentist-in-Chief, Department of Dentistry, The Hospital for Sick Children, and an associate professor, Dentistry, University of Toronto, in Toronto, ON, Canada.

出版信息

Pediatr Dent. 2017 Jan 15;39(1):34-38.

PMID:28292339

Abstract

PURPOSE

The purpose of this study was to compare outcomes and survival of ferric sulfate with mineral trioxide aggregate (FS+MTA) pulpotomy and root canal therapy (RCT) in carious vital primary maxillary incisors.

METHODS

In this parallel group noninferiority trial, asymptomatic carious vital primary incisors with pulp exposure in healthy 18- to 46-month-olds were allocated randomly to receive FS+MTA pulpotomy or RCT between September 2010 and September 2012. Each incisor was classified into one of the following radiographic outcomes: N (incisor without pathologic change); Po (pathologic change present, follow-up recommended); Px (pathologic change present, extract.) Clinical findings and incisor survival were secondary outcomes.

RESULTS

Seventy subjects were enrolled with a total of 172 incisors. Twelve- and 18-month radiographic outcomes demonstrated no statistical difference between FS+MTA pulpotomy and RCT incisors for Px outcomes (P=0.38; odds ratio equals 0.60; 95 percent confidence interval equals 0.19 to 1.89; chi-square test). There was no statistical differences in clinical outcomes for FS+MTA pulpotomy and RCT at 12 and 18 months (P=0.51; Fisher's exact test) or survival for FS+MTA pulpotomy and RCT incisors (P=0.11; log-rank test).

CONCLUSIONS

Ferric Sulfate with Mineral Trioxide Aggregate (FS+MTA) is an alternative to RCT for vital primary incisors.

摘要

目的

本研究旨在比较硫酸铁与三氧化矿物凝聚体（FS+MTA）活髓切断术和根管治疗术（RCT）治疗龋源性活髓上颌乳切牙的疗效和生存率。

方法

在这项平行组非劣效性试验中，2010年9月至2012年9月期间，将18至46个月健康儿童中无症状且龋源性活髓暴露的乳切牙随机分配接受FS+MTA活髓切断术或RCT。每颗切牙分为以下影像学结果之一：N（切牙无病理改变）；Po（存在病理改变，建议随访）；Px（存在病理改变，拔除）。临床检查结果和切牙生存率为次要结果。

结果

共纳入70名受试者，总计172颗切牙。12个月和18个月时的影像学结果显示，FS+MTA活髓切断术和RCT治疗的切牙在Px结果方面无统计学差异（P=0.38；优势比等于0.60；95%置信区间等于0.19至1.89；卡方检验）。FS+MTA活髓切断术和RCT在12个月和18个月时的临床结果无统计学差异（P=0.51；Fisher精确检验），FS+MTA活髓切断术和RCT治疗的切牙生存率也无统计学差异（P=0.11；对数秩检验）。