胰腺癌基因组学 2.0：转移分析。
Pancreatic Cancer Genomics 2.0: Profiling Metastases.
机构信息
Helen Diller Comprehensive Cancer Center, Department of Medicine, University of California San Francisco, San Francisco, CA 94158, USA.
Departments of Pathology and Translational Molecular Pathology, Sheikh Ahmed Pancreatic Cancer Research Center, UT MD Anderson Cancer Center, Houston, TX 77030, USA.
出版信息
Cancer Cell. 2017 Mar 13;31(3):309-310. doi: 10.1016/j.ccell.2017.02.014.
Pancreatic ductal adenocarcinoma, even when diagnosed early, nearly always metastasizes. Recurrent mutations and genomic instability are early events in the disease. Two recent papers advance our understanding of how the cancer genome evolves as the primary tumor migrates from its origin in the pancreas to colonize distant metastatic sites.
胰腺导管腺癌，即使在早期诊断，几乎总是发生转移。复发突变和基因组不稳定性是疾病的早期事件。最近的两篇论文增进了我们对癌症基因组如何随着原发性肿瘤从胰腺起源迁移到定植远处转移部位而进化的理解。
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