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BET Inhibition Induces Apoptosis in Aggressive B-Cell Lymphoma via Epigenetic Regulation of BCL-2 Family Members.
Mol Cancer Ther. 2016 Sep;15(9):2030-41. doi: 10.1158/1535-7163.MCT-15-0924. Epub 2016 Jul 12.
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The BET inhibitor JQ1 selectively impairs tumour response to hypoxia and downregulates CA9 and angiogenesis in triple negative breast cancer.
Oncogene. 2017 Jan 5;36(1):122-132. doi: 10.1038/onc.2016.184. Epub 2016 Jun 13.
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MYC and BCL2 overexpression is associated with a higher class of Memorial Sloan-Kettering Cancer Center prognostic model and poor clinical outcome in primary diffuse large B-cell lymphoma of the central nervous system.
BMC Cancer. 2016 Jun 10;16:363. doi: 10.1186/s12885-016-2397-8.
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BET bromodomain inhibitors suppress EWS-FLI1-dependent transcription and the IGF1 autocrine mechanism in Ewing sarcoma.
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MYC regulates the antitumor immune response through CD47 and PD-L1.
Science. 2016 Apr 8;352(6282):227-31. doi: 10.1126/science.aac9935. Epub 2016 Mar 10.
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c-myc copy number gain is a powerful prognosticator of disease outcome in cervical dysplasia.
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Non-metastatic 2 (NME2)-mediated suppression of lung cancer metastasis involves transcriptional regulation of key cell adhesion factor vinculin.
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Promoter-proximal transcription factor binding is transcriptionally active when coupled with nucleosome repositioning in immediate vicinity.
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Intravesical instillation of c-MYC inhibitor KSI-3716 suppresses orthotopic bladder tumor growth.
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Disruption of Myc-Max heterodimerization with improved cell-penetrating analogs of the small molecule 10074-G5.
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