萘霉素，耐甲氧西林金黄色葡萄球菌中β-内酰胺耐药性的新型规避剂，由链霉菌属KB-3346-5产生。I. 产生菌的分类学，以及发酵、分离和抗菌活性。
Naphthacemycins, novel circumventors of β-lactam resistance in MRSA, produced by Streptomyces sp. KB-3346-5. I. The taxonomy of the producing strain, and the fermentation, isolation and antibacterial activities.
作者信息
Fukumoto Atsushi, Kim Yong-Pil, Matsumoto Atsuko, Takahashi Yoko, Suzuki Makoto, Onodera Hideyuki, Tomoda Hiroshi, Matsui Hidehito, Hanaki Hideaki, Iwatsuki Masato, Ōmura Satoshi, Shiomi Kazuro
机构信息
Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan.
Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan.
出版信息
J Antibiot (Tokyo). 2017 May;70(5):562-567. doi: 10.1038/ja.2017.28. Epub 2017 Mar 15.
Screening for circumventors of β-lactam resistance in methicillin-resistant Staphylococcus aureus (MRSA) led us to find 17 novel antibiotics, naphthacemycins A-A, B-B and C-C. The naphthacemycins were isolated from a cultured broth of Streptomyces sp. KB-3346-5 by repeated silica gel column chromatography and HPLC. Naphthacemycins enhanced imipenem activity 100-500 times against MRSA at 0.5 μg ml, and naphthacemycins A-A themselves showed MIC values of 1-4 μg ml against 22 MRSA strains.
对耐甲氧西林金黄色葡萄球菌（MRSA）中β-内酰胺耐药规避机制的筛选，使我们发现了17种新型抗生素，即萘并霉素A-A、B-B和C-C。这些萘并霉素是通过反复硅胶柱色谱法和高效液相色谱法从链霉菌属KB-3346-5的培养液中分离得到的。在0.5μg/ml浓度下，萘并霉素使亚胺培南对MRSA的活性增强了100至500倍，并且萘并霉素A-A自身对22株MRSA菌株的最低抑菌浓度（MIC）值为1至4μg/ml。
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