• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

萘霉素，耐甲氧西林金黄色葡萄球菌中β-内酰胺耐药性的新型规避剂，由链霉菌属KB-3346-5产生。I. 产生菌的分类学，以及发酵、分离和抗菌活性。

Naphthacemycins, novel circumventors of β-lactam resistance in MRSA, produced by Streptomyces sp. KB-3346-5. I. The taxonomy of the producing strain, and the fermentation, isolation and antibacterial activities.

作者信息

Fukumoto Atsushi, Kim Yong-Pil, Matsumoto Atsuko, Takahashi Yoko, Suzuki Makoto, Onodera Hideyuki, Tomoda Hiroshi, Matsui Hidehito, Hanaki Hideaki, Iwatsuki Masato, Ōmura Satoshi, Shiomi Kazuro

机构信息

Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan.

Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan.

出版信息

J Antibiot (Tokyo). 2017 May;70(5):562-567. doi: 10.1038/ja.2017.28. Epub 2017 Mar 15.

DOI:10.1038/ja.2017.28
PMID:28293038
Abstract

Screening for circumventors of β-lactam resistance in methicillin-resistant Staphylococcus aureus (MRSA) led us to find 17 novel antibiotics, naphthacemycins A-A, B-B and C-C. The naphthacemycins were isolated from a cultured broth of Streptomyces sp. KB-3346-5 by repeated silica gel column chromatography and HPLC. Naphthacemycins enhanced imipenem activity 100-500 times against MRSA at 0.5 μg ml, and naphthacemycins A-A themselves showed MIC values of 1-4 μg ml against 22 MRSA strains.

摘要

对耐甲氧西林金黄色葡萄球菌（MRSA）中β-内酰胺耐药规避机制的筛选，使我们发现了17种新型抗生素，即萘并霉素A-A、B-B和C-C。这些萘并霉素是通过反复硅胶柱色谱法和高效液相色谱法从链霉菌属KB-3346-5的培养液中分离得到的。在0.5μg/ml浓度下，萘并霉素使亚胺培南对MRSA的活性增强了100至500倍，并且萘并霉素A-A自身对22株MRSA菌株的最低抑菌浓度（MIC）值为1至4μg/ml。

相似文献

1
Naphthacemycins, novel circumventors of β-lactam resistance in MRSA, produced by Streptomyces sp. KB-3346-5. I. The taxonomy of the producing strain, and the fermentation, isolation and antibacterial activities.萘霉素，耐甲氧西林金黄色葡萄球菌中β-内酰胺耐药性的新型规避剂，由链霉菌属KB-3346-5产生。I. 产生菌的分类学，以及发酵、分离和抗菌活性。
J Antibiot (Tokyo). 2017 May;70(5):562-567. doi: 10.1038/ja.2017.28. Epub 2017 Mar 15.
2
Naphthacemycins, novel circumventors of β-lactam resistance in MRSA, produced by Streptomyces sp. KB-3346-5. II. Structure elucidation.萘霉素，由链霉菌属KB - 3346 - 5产生的耐甲氧西林金黄色葡萄球菌中β-内酰胺抗性的新型规避剂。II. 结构解析。
J Antibiot (Tokyo). 2017 May;70(5):568-573. doi: 10.1038/ja.2017.29. Epub 2017 Mar 15.
3
Cyslabdan, a new potentiator of imipenem activity against methicillin-resistant Staphylococcus aureus, produced by Streptomyces sp. K04-0144. II. Biological activities.西斯拉丹，一种由链霉菌属K04 - 0144产生的新型亚胺培南对耐甲氧西林金黄色葡萄球菌活性增强剂。II. 生物学活性。
J Antibiot (Tokyo). 2008 Jan;61(1):7-10. doi: 10.1038/ja.2008.102.
4
The synergistic antibacterial activity of 1-acetyl-beta-carboline and beta-lactams against methicillin-resistant Staphylococcus aureus (MRSA).1-乙酰-β-咔啉与β-内酰胺类抗生素对耐甲氧西林金黄色葡萄球菌（MRSA）的协同抗菌活性。
J Microbiol Biotechnol. 2010 Mar;20(3):501-5.
5
Cyslabdan, a new potentiator of imipenem activity against methicillin-resistant Staphylococcus aureus, produced by Streptomyces sp. K04-0144. I. Taxonomy, fermentation, isolation and structural elucidation.Cyslabdan，一种由链霉菌属K04 - 0144产生的新型亚胺培南抗耐甲氧西林金黄色葡萄球菌活性增强剂。I. 分类学、发酵、分离及结构解析。
J Antibiot (Tokyo). 2008 Jan;61(1):1-6. doi: 10.1038/ja.2008.101.
6
Xanthoradones, new potentiators of imipenem activity against methicillin-resistant Staphylococcus aureus, produced by Penicillium radicum FKI-3765-2: I. Taxonomy, fermentation, isolation and biological properties.由根状青霉FKI-3765-2产生的新型亚黄红菌素，作为亚胺培南对耐甲氧西林金黄色葡萄球菌活性的增强剂：I. 分类学、发酵、分离及生物学特性
J Antibiot (Tokyo). 2009 Aug;62(8):431-4. doi: 10.1038/ja.2009.69. Epub 2009 Jul 24.
7
Stemphones, novel potentiators of imipenem activity against methicillin-resistant staphylococcus aureus, produced by Aspergillus sp. FKI-2136.由曲霉属FKI-2136菌株产生的茎菌素，是亚胺培南对耐甲氧西林金黄色葡萄球菌活性的新型增效剂。
J Antibiot (Tokyo). 2005 Nov;58(11):695-703. doi: 10.1038/ja.2005.95.
8
Restoring methicillin-resistant Staphylococcus aureus susceptibility to β-lactam antibiotics.恢复耐甲氧西林金黄色葡萄球菌对β-内酰胺类抗生素的敏感性。
Sci Transl Med. 2012 Mar 21;4(126):126ra35. doi: 10.1126/scitranslmed.3003592.
9
NW-G01, a novel cyclic hexadepsipeptide antibiotic, produced by Streptomyces alboflavus 313: I. Taxonomy, fermentation, isolation, physicochemical properties and antibacterial activities.NW-G01，一种由黄白色链霉菌313产生的新型环状六肽缩酚酸肽抗生素：I. 分类学、发酵、分离、理化性质及抗菌活性
J Antibiot (Tokyo). 2009 Apr;62(4):201-5. doi: 10.1038/ja.2009.15. Epub 2009 Mar 6.
10
Discovery of nosokophic acid, a predicted intermediate of moenomycins, from nosokomycin-producing Streptomyces sp. K04-0144.从产生诺西霉素的链霉菌 sp. K04-0144 中发现诺西酸，这是莫能菌素的一种预测中间体。
Bioorg Med Chem Lett. 2013 Feb 1;23(3):860-3. doi: 10.1016/j.bmcl.2012.11.044. Epub 2012 Nov 29.

引用本文的文献

1
Mangrove pneumatophores as biocatalysts for the fabrication of silver nanoparticles and their potential applications against biofilm formation and hepatic carcinoma.红树林气生根作为制备银纳米颗粒的生物催化剂及其在抗生物膜形成和肝癌方面的潜在应用。
Nanoscale Adv. 2025 Mar 3;7(9):2608-2625. doi: 10.1039/d4na00722k. eCollection 2025 Apr 29.
2
Total Synthesis of the Phenylnaphthacenoid Type II Polyketide Antibiotic Formicamycin H via Regioselective Ruthenium-Catalyzed Hydrogen Auto-Transfer [4 + 2] Cycloaddition.通过区域选择性钌催化氢自动转移[4 + 2]环加成反应全合成苯并萘醌型 II 聚酮抗生素福米卡霉素 H。
J Am Chem Soc. 2024 Sep 25;146(38):26351-26359. doi: 10.1021/jacs.4c09068. Epub 2024 Sep 12.
3
Heterologous Expression of the Formicamycin Biosynthetic Gene Cluster Unveils Glycosylated Fasamycin Congeners.
异源表达(formicamycin)生物合成基因簇揭示糖基化 fasamycin 同系物。
J Nat Prod. 2023 Jul 28;86(7):1677-1689. doi: 10.1021/acs.jnatprod.3c00052. Epub 2023 Jun 16.
4
Discovery of New Antibacterial Accramycins from a Genetic Variant of the Soil Bacterium, sp. MA37.从土壤细菌 sp. MA37 的遗传变异体中发现新的抗菌 Accramycins
Biomolecules. 2020 Oct 20;10(10):1464. doi: 10.3390/biom10101464.
5
Mersaquinone, A New Tetracene Derivative from the Marine-Derived sp. EG1 Exhibiting Activity against Methicillin-Resistant (MRSA).甲基萘醌，一种源自海洋来源的sp. EG1的新型并四苯衍生物，对耐甲氧西林金黄色葡萄球菌（MRSA）具有活性。
Antibiotics (Basel). 2020 May 14;9(5):252. doi: 10.3390/antibiotics9050252.
6
Accramycin A, a New Aromatic Polyketide, from the Soil Bacterium, MA37.阿克拉霉素 A，一种新型芳香族聚酮，来源于土壤细菌 MA37。
Molecules. 2019 Sep 17;24(18):3384. doi: 10.3390/molecules24183384.