Kim Min Cheol, Cullum Reiko, Hebishy Ali M S, Mohamed Hala A, Faraag Ahmed H I, Salah Nehad M, Abdelfattah Mohamed S, Fenical William
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093, USA.
Natural Products Research Unit, Chemistry Department, Faculty of Science, Helwan University, Cairo 11795, Egypt.
Antibiotics (Basel). 2020 May 14;9(5):252. doi: 10.3390/antibiotics9050252.
New antibiotics are desperately needed to overcome the societal challenges being encountered with methicillin-resistant (MRSA). In this study, a new tetracene derivative, named Mersaquinone (), and the known Tetracenomycin D (), Resistoflavin () and Resistomycin () have been isolated from the organic extract of the marine sp. EG1. The strain was isolated from a sediment sample collected from the North Coast of the Mediterranean Sea of Egypt. The chemical structure of Mersaquinone () was assigned based upon data from a diversity of spectroscopic techniques including HRESIMS, IR, 1D and 2D NMR measurements. Mersaquinone () showed antibacterial activity against methicillin-resistant with a minimum inhibitory concentration of 3.36 μg/mL.
迫切需要新的抗生素来应对耐甲氧西林金黄色葡萄球菌（MRSA）所带来的社会挑战。在本研究中，从海洋菌株EG1的有机提取物中分离出一种名为Mersaquinone（）的新型并四苯衍生物，以及已知的并四苯霉素D（）、抗荧光素（）和抗霉素（）。该菌株是从埃及地中海北海岸采集的沉积物样本中分离出来的。基于包括高分辨电喷雾电离质谱（HRESIMS）、红外光谱（IR）、一维和二维核磁共振测量等多种光谱技术的数据确定了Mersaquinone（）的化学结构。Mersaquinone（）对耐甲氧西林金黄色葡萄球菌显示出抗菌活性，最低抑菌浓度为3.36μg/mL。
