脂蛋白脂肪酶基因多态性作为哥伦比亚人群中风的遗传标志物：一项病例对照研究。
Polymorphisms of the lipoprotein lipase gene as genetic markers for stroke in colombian population: a case control study.
作者信息
Velásquez Pereira Leydi Carolina, Vargas Castellanos Clara Inés, Silva Sieger Federico Arturo
机构信息
Departamento de Ciencias Básicas, Facultad de Salud, Universidad Industrial de Santander, Bucaramenga, Colombia.
Grupo de Ciencias Neurovasculares. Fundación Cardiovascular de Colombia, Bucaramanga, Colombia.
出版信息
Colomb Med (Cali). 2016 Dec 30;47(4):189-195.
OBJECTIVE
To analyze if there is an association between the presence of polymorphisms in the gene (rs320, rs285 and rs328) with development of acute ischemic stroke in Colombian population.
METHODS
In a case control design, 133 acute ischemic stroke patients (clinical diagnosis and x-ray CT) and 269 subjects without stroke as controls were studied. PCR -RFLP technique was used to detect rs320, rs285 and rs328 polymorphisms in the LPL gene.
RESULTS
In the present research was not found any association between any of the LPL gene polymorphism and acute ischemic stroke in the population studied; the allele and genotypic frequencies of the studied polymorphisms were similar in cases and controls and followed the Hardy-Weinberg equilibrium. The study was approved by the IRB and each subject signed the informed consent.
CONCLUSION
LPL gene polymorphisms are not genetic markers for the development of stroke in the Colombian sample used.
目的
分析基因（rs320、rs285和rs328）中的多态性与哥伦比亚人群急性缺血性脑卒中发生之间是否存在关联。
方法
采用病例对照设计，对133例急性缺血性脑卒中患者（临床诊断及X线CT检查）和269例无脑卒中的受试者作为对照进行研究。运用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）技术检测脂蛋白脂肪酶（LPL）基因中的rs320、rs285和rs328多态性。
结果
在本研究中，未发现所研究人群中任何LPL基因多态性与急性缺血性脑卒中之间存在关联；所研究多态性的等位基因和基因型频率在病例组和对照组中相似，且符合哈迪-温伯格平衡。该研究经机构审查委员会（IRB）批准，每位受试者均签署了知情同意书。
结论
在所使用的哥伦比亚样本中，LPL基因多态性不是脑卒中发生的遗传标志物。
Zotero 插件