Jalalzadeh Mojgan, Ghadiani Mohammad Hassan, Mousavinasab Nouraddin
Departments of Nephrology , Imam Hossein Hospital , Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Nephrology. Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
J Nephropathol. 2012 Oct;1(3):170-6. doi: 10.5812/nephropathol.8115. Epub 2012 Oct 1.
In dialysis patients, chronic infections have been associated with cachexia and anorexia.
This study was carried out to determine the association between Helicobacter pylori (HP) infection and body mass index (BMI) in hemodialysis (HD) patients.
Ninety eight patients were divided into two groups of negative (group 1) and positive (group 2), for HP. BMI of all patients was measured at the beginning and in group2 after six months following eradication of HP. Before dialysis, various paraclinical parameters were checked at the same intervals.
Fifty-nine patients were enrolled in group 1 and 39 patients in group 2. The means of BMI in groups 1 and 2 were 23.4±3.7 and 25.8±4.4kg/m², respectively. Prior to the study, there was no significant difference for BMI, duration of HD and paraclinic data between two groups. Group 2 took anti HP therapy and eradication occurred in 30 of them. In this group six months after eradication of HP, the BMI was significantly decreased from 25.02±4.4 to 24.4±4.0 kg/m² (P = 0.001). Also six months following the eradication of HP, the mean of serum albumin level was significantly declined from 4.2 to 3.7 g/L (P<0.001). There was also significant decrease in cholesterol (P=0.001), blood urea nitrogen (P=0.005) and calcium (P=0.02). However, significant increase in hemoglobin level was also seen (P=0.03).
The results of this study show that eradication of HP has an impact on BMI. The results need to be investigated with larger cases.
在透析患者中，慢性感染与恶病质和厌食症有关。
本研究旨在确定血液透析（HD）患者中幽门螺杆菌（HP）感染与体重指数（BMI）之间的关联。
98例患者分为HP阴性组（第1组）和阳性组（第2组）。所有患者在开始时测量BMI，第2组在根除HP六个月后再次测量。透析前，以相同间隔检查各种辅助临床参数。
第1组纳入59例患者，第2组纳入39例患者。第1组和第2组的BMI均值分别为23.4±3.7和25.8±4.4kg/m²。研究前，两组之间的BMI、HD持续时间和辅助临床数据无显著差异。第2组接受抗HP治疗，其中30例根除。在该组根除HP六个月后，BMI从25.02±4.4显著降至24.4±4.0kg/m²（P = 0.001）。同样，根除HP六个月后，血清白蛋白水平均值从4.2显著降至3.7g/L（P<0.001）。胆固醇（P = 0.001）、血尿素氮（P = 0.005）和钙（P = 0.02）也显著降低。然而，血红蛋白水平也显著升高（P = 0.03）。
本研究结果表明根除HP对BMI有影响。结果需要用更大样本量进行研究。
