Nezhad Behgol Nemati, Allahverdi Bahar, Motamed Farzaneh, Djalalinia Shirin, Askarian Fahimeh, Fahimi Daryoush, Bazargani Behnaz, Abbasi Arash, Moghtaderi Mastaneh
Resident of Pediatric Course, Children Medical Center Hospital Tehran University of Medical Sciences Tehran Iran.
Pediatric Gastroenterology and Hepatology Research Center, Children's Medical Center, The Pediatric Center of Excellence Tehran University of Medical Sciences Tehran Iran.
Clin Case Rep. 2024 Jul 3;12(7):e9157. doi: 10.1002/ccr3.9157. eCollection 2024 Jul.
As there is no significant mutual relationship between infection and chronic kidney disease in children, its routine study is not justified and is recommended only in symptomatic cases.
Children suffering from chronic kidney disease (CKD) often complain of indigestion but, if it is accompanied by abdominal pain, it is necessary to investigate and rule out Helicobacter pylori infection to confirm functional dyspepsia. Epidemiological studies in adults have conflicting results regarding the association between infection and CKD. In this study, we determined the prevalence of in children with kidney failure and its relationship to their gastrointestinal symptoms. In this retrospective study, 54 children with chronic kidney failure admitted to the hemodialysis ward of the Children's Medical Center, Tehran, Iran between 2012 and 2020 were studied. The mean age of our patients was 11.89 ± 3.99 years and their sex distribution was equal. infection was reported in only three patients with 5.6%. Based on our findings, epigastric pain in children was the most common gastrointestinal symptom (70.4%). Among all patients, three patients (5.6%) died, all of them were male (P = 0.075). The most prevalent underlying cause of kidney failure in our patients was neurogenic bladder. We did not find any significant relationship between the increased risk of chronic kidney failure and co-infection with . Investigating the cause of epigastric pain and looking for is very important in CKD children under hemodialysis because if they receive a transplant the possibility of gastrointestinal complications will be increased with the use of steroid and immunosuppressive drugs.
由于儿童感染与慢性肾脏病之间不存在显著的相互关系，因此对其进行常规检查并无依据，仅建议在有症状的病例中进行检查。
患有慢性肾脏病（CKD）的儿童常诉说消化不良，但如果伴有腹痛，则有必要进行检查并排除幽门螺杆菌感染以确诊功能性消化不良。关于感染与CKD之间的关联，成人流行病学研究结果相互矛盾。在本研究中，我们确定了肾衰竭患儿中幽门螺杆菌的感染率及其与胃肠道症状的关系。在这项回顾性研究中，我们对2012年至2020年间入住伊朗德黑兰儿童医学中心血液透析病房的54例慢性肾衰竭患儿进行了研究。我们患者的平均年龄为11.89±3.99岁，性别分布均衡。仅3例患者（5.6%）报告有幽门螺杆菌感染。根据我们的研究结果，上腹部疼痛是儿童最常见的胃肠道症状（70.4%）。所有患者中，3例（5.6%）死亡，均为男性（P = 0.075）。我们患者中肾衰竭最常见的潜在病因是神经源性膀胱。我们未发现慢性肾衰竭风险增加与幽门螺杆菌合并感染之间存在任何显著关系。对于接受血液透析的CKD患儿，调查上腹部疼痛的原因并寻找幽门螺杆菌非常重要，因为如果他们接受移植，使用类固醇和免疫抑制药物会增加胃肠道并发症的可能性。
